Evidence map›Paper›PMID 32060963›Full record

ArticleMagnetic resonance in medicine2020

Lumbar intervertebral disc characterization through quantitative MRI analysis: An automatic voxel-based relaxometry approach.

Claudia Iriondo, Valentina Pedoia, Sharmila Majumdar

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Artificial Intelligence and Computer Vision in Low Back Pain: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  5. HRNet-ACAP-Offset: a novel framework for localizing posterior edge landmark points in 3D intervertebral disc MRI.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
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  10. Deep Learning and Its Application to Function Approximation for MR in Medicine: An Overview.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Review
  11. The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022
    Observational
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Claudia IriondoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.ORCID 0000-0001-7646-6059
Valentina PedoiaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.
Sharmila MajumdarDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California.ORCID 0000-0002-0201-871X
University of California, San Francisco · US

Funding

Structural, Biochemical and Functional Connectivity in Osteoarthritis using Quantitative Magnetic Resonance Imaging and Skeletal BiomechanicsR01AR069006 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA, SOUZA, RICHARD BRIAN · 2016 to 2025
$7.2M
Technology Research Site for Advanced, Faster Quantitative Imaging for BACPACUH3AR076724 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2020 to 2023
$4.8M
Technology Research Site for Advanced, Faster Quantitative Imaging for BACPACUH2AR076724 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2019 to 2019
$514k
NIAMS NIH HHS UH2 AR076724NIAMS NIH HHS UH3 AR076724
6 · The paper itself

Abstract

purposeTo develop an automated pipeline based on convolutional neural networks to segment lumbar intervertebral discs and characterize their biochemical composition using voxel-based relaxometry, and establish local associations with clinical measures of disability, muscle changes, and other symptoms of lower back pain.

methodsThis work proposes a new methodology using MRI (n = 31, across the spectrum of disc degeneration) that combines deep learning-based segmentation, atlas-based registration, and statistical parametric mapping for voxel-based analysis of T

resultsAcross degenerative grades, the segmentation algorithm produced accurate, high-confidence segmentations of the lumbar discs in two independent data sets. Manually and automatically extracted mean disc T

conclusionThis work presented a scalable pipeline for fast, automated assessment of disc relaxation times, and voxel-based relaxometry that overcomes limitations of current region of interest-based analysis methods and may enable greater insights and associations between disc degeneration, disability, and lower back pain.

Indexed as

Intervertebral DiscIntervertebral Disc DegenerationHumansLumbar VertebraeLumbosacral RegionMagnetic Resonance Imagingdeep learningregistrationrelaxometrysegmentationspine

Identifiers

PMID32060963
PMCPMC7318328
OpenAlexW3005663714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.