Trial reportEuropean journal of applied physiology2020
Tracking the corticospinal responses to strength training.
Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Corticospinal effects and motor performance changes following resistance training in healthy adults: a systematic review and meta-analysis of transcranial magnetic stimulation.Frontiers in physiology · 2026Pooled it
- Pooled it
- Resistance training tempo selectively modulates corticospinal and reticulospinal excitability in humans.The Journal of physiology · 2026Trial
- Effects of Low-Load Blood-Flow Restriction Training Versus High-Load Resistance Training on Neuromuscular Performance and Neuromuscular Activation.Scandinavian journal of medicine & science in sports · 2026Trial
- Can the cross-education of strength attenuate the impact of detraining after a period of strength training? A quasi-randomized trial.European journal of applied physiology · 2024Trial
- Effects of Strength Training on Cognitive Function, Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 in Highly-Trained Young Female Soccer Players.Sports medicine - open · 2026Article
- Novel evidence of age-related cortical and subcortical constraints in cross-education.GeroScience · 2026Article
- Age-related differences in corticospinal and reticulospinal adaptations to short-term strength training.European journal of applied physiology · 2026Article
- Effect of physical activity on paired-pulse suppression in the somatosensory cortex after tibial nerve stimulation.Experimental brain research · 2026Article
- Twelve Weeks of In-Season Strength Training at Moderate Intensities Improve Strength and Body Composition Without Increasing Muscle Damage or Inflammation in Elite Young Female Soccer Players.Sports (Basel, Switzerland) · 2026Article
- Muscle activation and intermuscular coordination adaptations to early strength training during maximal force production.PloS one · 2026Article
- Reticulospinal and corticospinal responses in long-term strength-trained and untrained adults.European journal of applied physiology · 2025Article
- Effects and mechanisms of resistance training on corticospinal adaptation.Frontiers in physiology · 2025Review
- Corticospinal and spinal responses following a single session of lower limb motor skill and resistance training.European journal of applied physiology · 2024Article
- Effects of Tempo-Controlled Resistance Training on Corticospinal Tract Plasticity in Healthy Controls: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Altitude-induced effects on neuromuscular, metabolic and perceptual responses before, during and after a high-intensity resistance training session.European journal of applied physiology · 2023Article
- Enhanced skeletal muscle contractile function and corticospinal excitability precede strength and architectural adaptations during lower-limb resistance training.European journal of applied physiology · 2023Article
- Identifying the role of the reticulospinal tract for strength and motor recovery: A scoping review of nonhuman and human studies.Physiological reports · 2023Article
- Does the reticulospinal tract mediate adaptation to resistance training in humans?Journal of applied physiology (Bethesda, Md. : 1985) · 2022Review
- Impaired motor control after sport-related concussion could increase risk for musculoskeletal injury: Implications for clinical management and rehabilitation.Journal of sport and health science · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe motor cortex (M1) appears to be a primary site of adaptation following both a single session, and repeated strength-training sessions across multiple weeks. Given that a single session of strength-training is sufficient to induce modification at the level of the M1 and corticospinal tract, this study sought to determine how these acute changes in M1 and corticospinal tract might accumulate across the course of a 2-week heavy-load strength-training program.
methodsTranscranial magnetic stimulation (TMS) was used to infer corticospinal excitability (CSE), intracortical facilitation (ICF), short and long-interval intracortical inhibition (SICI and LICI) and silent period duration prior to and following each training session during a 2-week heavy-load strength-training period.
resultsFollowing 2-weeks of strength-training, increases in strength (15.5%, P = 0.01) were accompanied by an increase in CSE (44%, P = 0.006) and reductions in both silent period duration (14%, P < 0.0001) and SICI (35%, P = 0.0004). Early training sessions acutely increased CSE and ICF, and acutely reduced silent period duration and SICI. However, later training sessions failed to modulate SICI and ICF, with substantial adaptations occurring offline between training sessions. No acute or retained changes in LICI were observed. Co-contraction of antagonists reduced by 36% following 2-weeks of strength-training.
conclusionsCollectively, these results indicate that corticospinal plasticity occurs within and between training sessions throughout a training period in distinct early and later stages that are modulated by separate mechanisms of plasticity. The development of strength is akin to the previously reported changes that occur following motor skill training.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.