ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
Health-related quality of life and distress in elderly vs. younger patients with high-grade glioma-results of a multicenter study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prevalence and management of sleep disturbance in adults with primary brain tumours and their caregivers: a systematic review.Journal of neuro-oncology · 2023Pooled it
- Health-related quality of life outcomes of surgery for diffuse glioma: A systematic review and pooled analysis.Neuro-oncology practice · 2026Review
- Radiomics-based machine learning for glioma grade classification: a multicenter study with SHapley Additive exPlanations interpretability analysis.Translational cancer research · 2025Article
- Empower GBM: A pilot study of a patient-caregiver supportive intervention for patients with glioblastoma.Palliative & supportive care · 2025Article
- Psychological burden in patients with sellar masses under conservative and surgical management.Neurosurgical review · 2025Article
- Parenting Concerns, Psychological Distress, and Relationship Adjustment Among Patients With Cancer and Their Partners: A Longitudinal Study.Psycho-oncology · 2025Article
- Health-Related Quality of Life and Treatment Satisfaction of Patients with Malignant IDH Wild-Type Gliomas and Their Caregivers.Current oncology (Toronto, Ont.) · 2024Article
- Use of complementary therapies and supportive measures of patients with intracranial gliomas-a prospective evaluation in an outpatient clinic.Journal of neuro-oncology · 2024Article
- The relationship between social determinants of health and neurocognitive and mood-related symptoms in the primary brain tumor population: A systematic review.Neuro-oncology practice · 2024Review
- Glioblastoma in the oldest old: Clinical characteristics, therapy, and outcome in patients aged 80 years and older.Neuro-oncology practice · 2024Article
- SV2B/miR-34a/miR-128 axis as prognostic biomarker in glioblastoma multiforme.Scientific reports · 2024Article
- Palliative care referral across the disease trajectory in high-grade glioma.Journal of neuro-oncology · 2023Article
- Distress in Neuro-Oncology Patients and Its Implications for Communication.Journal of the advanced practitioner in oncology · 2023Article
- Neural Regulation of Cancer: Cancer-Induced Remodeling of the Central Nervous System.Advanced biology · 2022Review
- Psychological resilience is related to postoperative adverse events and quality of life in patients with glioma: a retrospective cohort study.Translational cancer research · 2022Article
- Postoperative Long-Term Independence Among the Elderly With Meningiomas: Function Evolution, Determinant Identification, and Prediction Model Development.Frontiers in oncology · 2021Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHalf of all newly diagnosed patients with glioblastoma are > 65 years still with a poor prognosis. Preserving quality of life is of high importance. However, patient reported outcome (PRO) data in this patient group is rare. The aim was to compare health-related quality of life (HRQoL) and distress between elderly and younger patients with high-grade glioma (HGG).
methodsWe used baseline data of a prospective study where HGG patients were enrolled from 4 hospitals. Distress was measured using the distress thermometer (DT), HRQoL using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) plus brain module (BN20). We compared distress and HRQoL by age (≥ 65 vs. < 65 years), gender, performance score, and time since diagnosis using multivariate linear and logistic regressions.
resultsA total of n = 93 (30%) out of n = 309 patients were ≥ 65 years (mean 70 years, range 65-86 years). Mean DT score of elderly patients (5.2, SD 2.6) was comparable with younger patients (4.9, SD 2.6). Elderly patients reported significantly lower global health (GHS, mean elderly vs. younger; 50.8 vs. 60.5, p = 0.003), worse physical (56.8 vs. 73.3, p < 0.001) and lower cognitive functioning (51.1 vs. 63.2, p = 0.002), worse fatigue (52.5 vs. 43.5, p = 0.042), and worse motor dysfunction (34.9 vs. 23.6, p = 0.030). KPS and not age was consistently associated with HRQoL.
conclusionPhysical functioning was significantly reduced in the elderly compared with younger HGG patients, and at the same time, emotional functioning and DT scores were comparable. KPS shows a greater association with HRQoL than with calendric age in HGG patients reflecting the particular importance for adequate assessment of HRQoL and general condition in elderly patients.
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