ArticleInternational journal of colorectal disease2020
A real-world, population-based study of the outcomes of patients with metastatic colorectal cancer to the peritoneum treated with or without cytoreductive surgery.
Article in International journal of colorectal disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Eighteen-Months Safety and Efficacy Following Intraperitoneal Treatment WithJournal of surgical oncology · 2024Trial
- Quxie Capsule Modulating Gut Microbiome and Its Association With T cell Regulation in Patients With Metastatic Colorectal Cancer: Result From a Randomized Controlled Clinical Trial.Integrative cancer therapiesTrial
- Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer.World journal of gastrointestinal oncology · 2024Article
- Cytoreductive surgery without intra-peritoneal chemotherapy for metachronous colorectal peritoneal metastases.World journal of surgical oncology · 2024Article
- A radiomics-boosted deep-learning for risk assessment of synchronous peritoneal metastasis in colorectal cancer.Insights into imaging · 2024Article
- Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments.Cancer metastasis reviews · 2024Review
- Peritoneal Metastasis: A Dilemma and Challenge in the Treatment of Metastatic Colorectal Cancer.Cancers · 2023Review
- A novel risk model for predicting peritoneal metastasis in colorectal cancer based on the SEER database.Journal of cancer research and clinical oncology · 2023Article
- Treatment and prognosis of colorectal cancer with synchronous peritoneal metastases: 11-year single institute experience.eGastroenterology · 2023Article
- First experience withFrontiers in medicine · 2023Article
- Impact of KRAS, BRAF and microsatellite instability status after cytoreductive surgery and HIPEC in a national cohort of colorectal peritoneal metastasis patients.British journal of cancer · 2022Article
- Development and Validation of a Prognostic Nomogram for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis.Frontiers in oncology · 2021Article
- Factors Prognostic for Peritoneal Metastases from Colorectal Cancer Treated with Surgery.Cancer management and research · 2020Article
- Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the outcomes of metastatic colorectal cancer patients with isolated peritoneal metastasis who were treated with or without cytoreductive surgery in a contemporary real-world, population-based cohort.
methodsSurveillance, Epidemiology, and End Results (SEER) database has been accessed and metastatic colorectal cancer patients to the peritoneum who have no evidence of other sites of distant metastases and who were diagnosed 2010-2015 were reviewed. Multivariable logistic regression analysis was then used to assess the patient- and treatment-related factors predicting the decision to do cytoreductive surgery. Kaplan-Meier survival estimates were used to compare overall survival according to cytoreductive surgery. Multivariable Cox regression analysis was additionally used to assess the impact of cytoreductive surgery on colorectal cancer-specific survival.
resultsA total of 3153 records were reviewed in the current analysis. Using Kaplan-Meier survival estimates, cytoreductive surgery was associated with improved overall survival (median overall survival, 19 months for patients with cytoreductive surgery versus 12 months for patients without cytoreductive surgery; P < 0.001). In an adjusted Cox regression model evaluating the impact of cytoreductive surgery on colorectal cancer-specific survival, cytoreductive surgery was associated with better colorectal cancer-specific survival (hazard ratio for death among patients who did not have cytoreductive surgery versus patients who had cytoreductive surgery, 1.312; 95% CI, 1.175-1.465; P < 0.001).
conclusionsCytoreductive surgery is associated with improved survival outcomes among colorectal cancer patients with peritoneal metastasis and no evidence of other distant metastases. Opimal utilization of this intervention needs to be further evaluated in prospective controlled trials.
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