ArticleThe Journal of infectious diseases2020
A Sialic Acid-Binding Protein SABP1 of Toxoplasma gondii Mediates Host Cell Attachment and Invasion.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Surface antigen SAG1 mediatesInfection and immunity · 2025Article
- A sialic acid-binding protein in Toxoplasma gondii contains a conserved globular domain in apicomplexan parasites.Parasites & vectors · 2025Article
- Low Tenacity ofMicroorganisms · 2025Article
- The TgAMPK-TgPFKII axis essentially regulates protein lactylation in the zoonotic parasiteMicrobiology spectrum · 2025Article
- Sialic Acid-Binding Protein-1 (SABP1) ofJournal of parasitology research · 2025Article
- Toxoplasma sortilin interacts with secretory proteins and it is critical for parasite proliferation.Parasites & vectors · 2024Article
- AFrontiers in cellular and infection microbiology · 2024Article
- Co-Immunization with DNA Vaccines Expressing SABP1 and SAG1 Proteins Effectively Enhanced Mice Resistance toVaccines · 2023Article
- Carbohydrates: Binding Sites and Potential Drug Targets for Neural-Affecting Pathogens.Advances in neurobiology · 2023Article
- Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes.Nature communications · 2022Article
- Sialic Acids as Receptors for Pathogens.Biomolecules · 2021Review
- The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection byFrontiers in cellular and infection microbiology · 2021Article
- The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus onFrontiers in cellular and infection microbiology · 2021Review
- Microneme Proteins 1 and 4 FromFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many obligate intracellular apicomplexan parasites have adapted a distinct invasion mechanism involving a close interaction between the parasite ligands and the sialic acid (SA) receptor. We found that sialic acid binding protein-1 (SABP1), localized on the outer membrane of the zoonotic parasite Toxoplasma gondii, readily binds to sialic acid on the host cell surface. The binding was sensitive to neuraminidase treatment. Cells preincubated with recombinant SABP1 protein resisted parasite invasion in vitro. The parasite lost its invasion capacity and animal infectivity after the SABP1 gene was deleted, whereas complementation of the SABP1 gene restored the virulence of the knockout strain. These data establish the critical role of SABP1 in the invasion process of T. gondii. The previously uncharacterized protein, SABP1, facilitated T. gondii attachment and invasion via sialic acid receptors.
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