Evidence map›Paper›PMID 32060388›Full record

ArticleScientific reports2020

Novel Ocellatin Peptides Mitigate LPS-induced ROS Formation and NF-kB Activation in Microglia and Hippocampal Neurons.

Nayara A Sousa, Guilherme A L Oliveira, Ana Patrícia de Oliveira, André Luís F Lopes, Bruno Iles, Kerolayne M Nogueira, Thiago S L Araújo, Luan K M Souza, Alyne R Araújo, Joilson Ramos-Jesus and 12 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 43 citations in OpenAlex.

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  10. Skin secretions of Leptodactylidae (Anura) and their potential applications.The journal of venomous animals and toxins including tropical diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Nayara A SousaLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Guilherme A L OliveiraLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Ana Patrícia de OliveiraLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.ORCID http://orcid.org/0000-0002-1994-9481
André Luís F LopesLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Bruno IlesLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Kerolayne M NogueiraLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Thiago S L AraújoLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Luan K M SouzaLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil.
Alyne R AraújoNúcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, UFPI, Piauí, Brazil.
Joilson Ramos-JesusNúcleo de Pesquisa em Biodiversidade e Biotecnologia, Universidade Federal do Piauí, UFPI, Piauí, Brazil.
Alexandra PlácidoLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.
Constança AmaralInstituto de Medicina Molecular, IMM, Universidade de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0001-6051-9494
Yuri D M CampeloInstituto de Educação Superior do Vale do Parnaíba, FAHESP/IESVAP/NRE, Parnaíba, Brazil.
Eder Alves BarbosaLaboratório de Síntese e Análise de Biomoléculas, LSAB, Instituto de Química, UnB, Brasília, Brazil.
Camila C PortugalLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.
Renato SocodatoLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.ORCID http://orcid.org/0000-0002-6882-5020
Andrea LoboLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.
Joao RelvasLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.
Marcelo BemquererEmbrapa Recursos Genéticos e Biotecnologia, Brasília, Brazil.
Peter EatonLAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciencias da Universidade do Porto, Porto, Portugal.
José Roberto S A LeiteNúcleo de Pesquisa em Morfologia e Imunonologia Aplicada, NuPMIA, Área Morfologia, Faculdade de Medicina, UnB, Brasília, Brazil.
Jand Venes R MedeirosLaboratório de Farmacologia da Inflamação e Doenças Gastrintestinais, Universidade Federal do Delta do Parnaíba, UFDPar, Piauí, Brazil. jandvenes@ufpi.edu.br.ORCID http://orcid.org/0000-0002-7234-3382
Universidade Federal do Piauí · BRUniversidade do Porto · PTUniversidade do Vale do Paraíba · BRUniversity of Lisbon · PTBrazilian Agricultural Research Corporation · BRUniversidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous secretions of amphibians have bioactive compounds, such as peptides, with potential for biotechnological applications. Therefore, this study aimed to determine the primary structure and investigate peptides obtained from the cutaneous secretions of the amphibian, Leptodactylus vastus, as a source of bioactive molecules. The peptides obtained possessed the amino acid sequences, GVVDILKGAAKDLAGH and GVVDILKGAAKDLAGHLASKV, with monoisotopic masses of [M + H]

Indexed as

Amino Acid SequenceAnimalsAntimicrobial Cationic PeptidesAnuraHippocampusInfectionsLipopolysaccharidesMiceMicrogliaNeuronsNF-kappa BNitritesReactive Oxygen SpeciesAntimicrobial Cationic PeptidesLipopolysaccharidesNF-kappa BNitritesReactive Oxygen Species

Identifiers

PMID32060388
PMCPMC7021831
OpenAlexW3006663812

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.