ArticleScientific reports2020
Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Corpus callosum fractional anisotropy from routine diffusion tensor imaging predicts dementia in older adults beyond clinical risk factors.GeroScience · 2026Article
- Evaluating regional and global diffusion measures as biomarkers for vascular contributions to cognitive impairment and dementia.Cerebral circulation - cognition and behavior · 2026Article
- Fractional Anisotropy Alterations in Key White Matter Pathways Associated with Cognitive Performance Assessed by MoCA.Neurology international · 2025Article
- Sagittal-oriented articular processes and intervertebral disc degeneration phenotypes can concurrently lead to an increased presence of annulus tears in the cranial adjacent motion segment : a clinical review and biomechanical simulation.Bone & joint research · 2025Article
- White Matter Abnormalities and Cognition in Aging and Alzheimer Disease.JAMA neurology · 2025Article
- Development and Validation of a Brain Aging Biomarker in Middle-Aged and Older Adults: Deep Learning Approach.JMIR aging · 2025Article
- Multimodal Classification of Alzheimer's Disease Using Longitudinal Data Analysis and Hypergraph Regularized Multi-Task Feature Selection.Bioengineering (Basel, Switzerland) · 2025Article
- Microstructural mapping of neural pathways in Alzheimer's disease using macrostructure-informed normative tractometry.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Functional MRI Assessment of Brain Activity Patterns Associated with Reading in Medulloblastoma Survivors.Brain sciences · 2024Article
- Field-of-view extension for brain diffusion MRI via deep generative models.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Sex, racial, andbioRxiv : the preprint server for biology · 2024Article
- Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle-Aged Individuals Without Stroke or Dementia.Journal of the American Heart Association · 2024Article
- Tracts in the limbic system show microstructural alterations post COVID-19 recovery.Brain communications · 2024Article
- White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer's disease continuum.Alzheimer's research & therapy · 2023Article
- Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging.bioRxiv : the preprint server for biology · 2023Article
- Structural alterations of the salience network in patients with insular glioma.Brain and behavior · 2023Article
- Identifying subcortical connectivity during brain tumor surgery: a multimodal study.Brain structure & function · 2023Article
- Docetaxel-induced cognitive impairment in rats can be ameliorated by edaravone dexborneol: Evidence from the indicators of biological behavior and anisotropic fraction.Frontiers in neuroscience · 2023Article
- Tract-specific differences in white matter microstructure between young adultNeuroimage. Reports · 2022Article
- Fitting Contralateral Neuroanatomical Asymmetry into the Amyloid Cascade Hypothesis.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current treatments for Alzheimer's disease are only symptomatic and limited to reduce the progression rate of the mental deterioration. Mild Cognitive Impairment, a transitional stage in which the patient is not cognitively normal but do not meet the criteria for specific dementia, is associated with high risk for development of Alzheimer's disease. Thus, non-invasive techniques to predict the individual's risk to develop Alzheimer's disease can be very helpful, considering the possibility of early treatment. Diffusion Tensor Imaging, as an indicator of cerebral white matter integrity, may detect and track earlier evidence of white matter abnormalities in patients developing Alzheimer's disease. Here we performed a voxel-based analysis of fractional anisotropy in three classes of subjects: Alzheimer's disease patients, Mild Cognitive Impairment patients, and healthy controls. We performed Support Vector Machine classification between the three groups, using Fisher Score feature selection and Leave-one-out cross-validation. Bilateral intersection of hippocampal cingulum and parahippocampal gyrus (referred as parahippocampal cingulum) is the region that best discriminates Alzheimer's disease fractional anisotropy values, resulting in an accuracy of 93% for discriminating between Alzheimer's disease and controls, and 90% between Alzheimer's disease and Mild Cognitive Impairment. These results suggest that pattern classification of Diffusion Tensor Imaging can help diagnosis of Alzheimer's disease, specially when focusing on the parahippocampal cingulum.
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