Evidence map›Paper›PMID 32060282›Full record

ArticleNature communications2020

Optoacoustic brain stimulation at submillimeter spatial precision.

Ying Jiang, Hyeon Jeong Lee, Lu Lan, Hua-An Tseng, Chen Yang, Heng-Ye Man, Xue Han, Ji-Xin Cheng

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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  15. Article
  16. Article
  17. High-Precision Photoacoustic Neural Modulation Uses a Non-Thermal Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  18. Review
  19. Force-Based Neuromodulation.Accounts of chemical research · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying JiangGraduate Program for Neuroscience, Boston University, Boston, MA, 02215, USA.
Hyeon Jeong LeePhotonics Center, Boston University, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-2417-9338
Lu LanPhotonics Center, Boston University, Boston, MA, 02215, USA.
Hua-An TsengDepartment of Biomedical Engineering, Boston University, Boston, MA, 02215, USA.
Chen YangPhotonics Center, Boston University, Boston, MA, 02215, USA.
Heng-Ye ManGraduate Program for Neuroscience, Boston University, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-3530-3066
Xue HanGraduate Program for Neuroscience, Boston University, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0003-3896-4609
Ji-Xin ChengGraduate Program for Neuroscience, Boston University, Boston, MA, 02215, USA. jxcheng@bu.edu.ORCID http://orcid.org/0000-0002-5607-6683

Funding

Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recordingR01NS109794 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN, HAN, XUE · 2018 to 2022
$3.6M
NINDS NIH HHS R01 NS109794
6 · The paper itself

Abstract

Low-intensity ultrasound is an emerging modality for neuromodulation. Yet, transcranial neuromodulation using low-frequency piezo-based transducers offers poor spatial confinement of excitation volume, often bigger than a few millimeters in diameter. In addition, the bulky size limits their implementation in a wearable setting and prevents integration with other experimental modalities. Here, we report spatially confined optoacoustic neural stimulation through a miniaturized Fiber-Optoacoustic Converter (FOC). The FOC has a diameter of 600 μm and generates omnidirectional ultrasound wave locally at the fiber tip through the optoacoustic effect. We show that the acoustic wave generated by FOC can directly activate individual cultured neurons and generate intracellular Ca

Indexed as

AnimalsBrainCalciumCells, CulturedFemaleMaleMiceMice, Inbred C57BLNeuronsPhotoacoustic TechniquesSpatial ProcessingUltrasonic WavesCalcium

Identifiers

PMID32060282
PMCPMC7021819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.