ArticleNature communications2020
Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 3 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 3 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.Nature communications · 2024Pooled it
- Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sex.EBioMedicine · 2023Pooled it
- Discovery of genomic loci associated with sleep apnea risk through multi-trait GWAS analysis with snoring.Sleep · 2023Pooled it
- Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Evaluation of environmental-genetic factors and mental health outcomes for sleep disturbance from late childhood to early adolescence.European child & adolescent psychiatry · 2026Article
- Sex differences in self-reported symptoms and comorbidities associated with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: A retrospective study.Research square · 2026Article
- Self-reported habitual snoring and health-related quality of life among adults attending community health centers in Shanghai, China: a cross-sectional study.Frontiers in public health · 2026Article
- Shared genetic architecture between Parkinson's disease and self-reported sleep-related traits implicates theSleep advances : a journal of the Sleep Research Society · 2026Article
- The relationship between healthy sleep patterns and the risk of scoliosis: a large prospective cohort study.Frontiers in neuroscience · 2026Article
- Genetic Association Between Sleep Traits and Vertigo Risk: A Two-sample Bidirectional Mendelian Randomization Study.Current molecular medicine · 2026Article
- Can we predict sleep health based on brain features? A large-scale machine learning study using the UK Biobank.Brain communications · 2026Article
- Genome-wide analysis in over 1.6 million participants uncovers 147 loci associated with obstructive sleep apnoea.medRxiv : the preprint server for health sciences · 2025Article
- Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Association of weekend catch-up sleep ratio with depressive risk: insights from NHANES 2021-2023.BMC psychiatry · 2025Article
- Snoring and its Associated Comorbidities.Sleep science (Sao Paulo, Brazil) · 2025Article
- The genetic overlap and causal relationship between attention deficit hyperactivity disorder and obstructive sleep apnea: a large-scale genomewide cross-trait analysis.BMC psychiatry · 2025Article
- Sleep characteristics and intervertebral disc degeneration risk: an observational and Mendelian randomization study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Observational
15 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Although snoring is common in the general population, its aetiology has been largely understudied. Here we report a genetic study on snoring (n ~ 408,000; snorers ~ 152,000) using data from the UK Biobank. We identify 42 genome-wide significant loci, with an SNP-based heritability estimate of ~10% on the liability scale. Genetic correlations with body mass index, alcohol intake, smoking, schizophrenia, anorexia nervosa and neuroticism are observed. Gene-based associations identify 173 genes, including DLEU7, MSRB3 and POC5, highlighting genes expressed in the brain, cerebellum, lungs, blood and oesophagus. We use polygenic scores (PGS) to predict recent snoring and probable obstructive sleep apnoea (OSA) in an independent Australian sample (n ~ 8000). Mendelian randomization analyses suggest a potential causal relationship between high BMI and snoring. Altogether, our results uncover insights into the aetiology of snoring as a complex sleep-related trait and its role in health and disease beyond it being a cardinal symptom of OSA.
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