Evidence map›Paper›PMID 32060102›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2020

Translating Basic Science Discoveries into Improved Outcomes for Glioblastoma.

Peter B Dirks, Mark R Gilbert, Eric C Holland, Elizabeth A Maher, William A Weiss

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. EGFR ligands dictate tumour suppression.Nature cell biology · 2022
    Article
  4. IFN-Computational intelligence and neuroscience · 2022
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peter B DirksDivision of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Mark R GilbertCenter for Cancer Research, NCI, Bethesda, Maryland.
Eric C HollandDivision of Human Biology, Clinical Research Division, Department of Neurosurgery, and Alvord Brain Tumor Center, University of Washington, Seattle, Washington.
Elizabeth A MaherDepartments of Internal Medicine and Neurology & Neurotherapeutics, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.
William A WeissDepartments of Neurology, Pediatrics, Neurological Surgery, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California. waweiss@gmail.com.

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Brain Tumor Clinical and Clinical Research Program (Clinical Support Services)ZIDBC011642 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OZER, BYRAM · 2015 to 2025
$23.4M
Mouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4M
Mechanisms and models of C11or95 and C11or95-RELA fusions (RELAFus )U54CA243125 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HOLLAND, ERIC C. · 2019 to 2022
$6.2M
Integrating targeted and immunotherapy to treat genetically heterogeneous cancersU01CA217864 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALMAIN, ALLAN, KRUMMEL, MATTHEW F · 2017 to 2021
$5.1M
Rare Central Nervous System Cancers InitiativeZIABC011643 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2015 to 2024
$4.2M
Identifying New Glioma-Associated Tumor Suppressors OncogenesZIABC011647 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2015 to 2024
$4.2M
Translational ImmunologyZIABC011714 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2016 to 2024
$4.0M
Exploring the Therapeutic Potential of Stem Cell Biology in GliomasZIABC011640 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GILBERT, MARK · 2015 to 2024
$3.1M
Improving the efficacy of mTOR inhibitionR01CA221969 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAN, QI WEN, SHOKAT, KEVAN M. · 2018 to 2022
$2.9M
Prevention and treatment of lethal metastases in group 3 medulloblastomaR01NS106155 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2018 to 2022
$2.8M
NCI NIH HHS P30 CA082103NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA159859NCI NIH HHS R01 CA221969NCI NIH HHS R01 CA244550NCI NIH HHS U01 CA217864NCI NIH HHS U54 CA243125NINDS NIH HHS R01 NS091620NINDS NIH HHS R01 NS106155
6 · The paper itself

Abstract

Members of the scientific and clinical neuro-oncology community met in April 2019 to discuss the current challenges and opportunities associated with translating basic science discoveries in glioblastoma for improved survival of patients. A summary of key points of these discussions is presented in this article.

Indexed as

Molecular Targeted TherapyTranslational Research, BiomedicalAntineoplastic AgentsGlioblastomaHumansAntineoplastic Agents

Identifiers

PMID32060102
PMCPMC7269826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.