ArticleeNeuro
Mapping of Sensory Nerve Subsets within the Vagal Ganglia and the Brainstem Using Reporter Mice for Pirt, TRPV1, 5-HT3, and Tac1 Expression.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 75 citations in OpenAlex.
- Cholecystokinin Induces CaThe European journal of neuroscience · 2026Article
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- Metastatic Cancers Exploit Vagal Sensory Neurons and Neural Repair Programs to Colonize New Tissues.Research square · 2026Article
- Efficient genetic perturbation of murine sensory neurons in vivo using CRISPR/Cas9.The journal of pain · 2026Article
- Article
- Are pulmonary neuroepithelial bodies sensors for acute airway hypoxia implicated in the central regulation of breathing?PloS one · 2026Article
- Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents.Scientific reports · 2025Article
- Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron-Mediated Lung-to-Brain Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents.Journal of neurophysiology · 2025Article
- Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents.Scientific reports · 2025Article
- Morphological Correlates of TRPV1 Agonist-Induced Activation and Defunctionalization of Nociceptor Neurons.International journal of molecular sciences · 2025Review
- Efficient genetic perturbation of murine sensory neuronsbioRxiv : the preprint server for biology · 2025Article
- Chemosensory tobacco product toxicology part 2: toxicological testing, assays, and state of the science.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Neuro-immune cross-talk in cancer.Nature reviews. Cancer · 2025Review
- Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation.Science advances · 2025Article
- Neural representation of cytokines by vagal sensory neurons.Nature communications · 2025Article
- Vagal Sensory Gut-Brain Pathways That Control Eating-Satiety and Beyond.Comprehensive physiology · 2025Review
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
- Brainstem opioid peptidergic neurons regulate cough reflexes in mice.Innovation (Cambridge (Mass.)) · 2024Article
- Investigation of vagal sensory neurons in mice using optical vagal stimulation and tracheal neuroanatomy.iScience · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Vagal afferent sensory nerves, originating in jugular and nodose ganglia, are composed of functionally distinct subsets whose activation evokes distinct thoracic and abdominal reflex responses. We used Cre-expressing mouse strains to identify specific vagal afferent populations and map their central projections within the brainstem. We show that Pirt is expressed in virtually all vagal afferents; whereas, 5-HT3 is expressed only in nodose neurons, with little expression in jugular neurons. Transient receptor potential vanilloid 1 (TRPV1), the capsaicin receptor, is expressed in a subset of small nodose and jugular neurons. Tac1, the gene for tachykinins, is expressed predominantly in jugular neurons, some of which also express TRPV1. Vagal fibers project centrally to the nucleus tractus solitarius (nTS), paratrigeminal complex, area postrema, and to a limited extent the dorsal motor nucleus of the vagus. nTS subnuclei preferentially receive projections by specific afferent subsets, with TRPV1
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.