Evidence map›Paper›PMID 32060024›Full record

ArticleApplied and environmental microbiology2020

Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies.

Mengdi Yang, Ge Zhu, George Korza, Xin Sun, Peter Setlow, Jiahe Li

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  12. Promoted Spore Formation ofIndian journal of microbiology · 2022
    Article
  13. Article
  14. Review
  15. Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2.Applied and environmental microbiology · 2022
    Article
  16. The multifunctionality of expression systems inExperimental biology and medicine (Maywood, N.J.) · 2021
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Mengdi YangDepartment of Bioengineering, Northeastern University, Boston, Massachusetts, USA.
Ge ZhuDepartment of Bioengineering, Northeastern University, Boston, Massachusetts, USA.
George KorzaDepartment of Molecular Biology and Biophysics, UCONN Health, Farmington, Connecticut, USA.
Xin SunDepartment of Bioengineering, Northeastern University, Boston, Massachusetts, USA.
Peter SetlowDepartment of Molecular Biology and Biophysics, UCONN Health, Farmington, Connecticut, USA.
Jiahe LiDepartment of Bioengineering, Northeastern University, Boston, Massachusetts, USA jiah.li@northeastern.edu.
Northeastern University · USUConn Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing need for a highly stable system to allow the production of biologics for diagnoses and therapeutic interventions on demand that could be used in extreme environments. Among the variety of biologics, nanobodies (Nbs) derived from single-chain variable antibody fragments from camelids have attracted great attention in recent years due to their small size and great stability with translational potentials in whole-body imaging and the development of new drugs. Intracellular expression using the bacterium

Indexed as

BioengineeringBacillus subtilisSingle-Domain AntibodiesSingle-Domain AntibodiesBacillus subtilismonoclonal antibodiesnanobodyprotein secretionrecombinant-protein productionsporessynthetic biology

Identifiers

PMID32060024
PMCPMC7117931
OpenAlexW3005999948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.