ArticleOphthalmology. Retina2020
Late-Onset Retinal Findings and Complications in Untreated Retinopathy of Prematurity.
Article in Ophthalmology. Retina, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07427719 (Children Treated for Retinopathy of Prematurity - Study of Visual Function and Retinal Structure), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Children Treated for Retinopathy of Prematurity - Study of Visual Function and Retinal Structure
Who cites it
41 citing papers in PubMed, 83 citations in OpenAlex.
- Risk factors and timing of ocular complications after screening for retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Incidence and Risk Factors for Persistent Avascular Retina in Patients with a History of Retinopathy of Prematurity in Mexico.Diagnostics (Basel, Switzerland) · 2026Article
- Surfactant proteins A and D nucleotide variants: association with retinal vascular disease.Pediatric research · 2026Article
- Long-Term Sequelae of Retinopathy of Prematurity-A Scoping Review.Children (Basel, Switzerland) · 2026Review
- Validating DevCheck: a semi-automated computer algorithm for measuring foveal immaturity in premature infants.Quantitative imaging in medicine and surgery · 2026Article
- PREVALENCE AND DEGREE OF RETINAL VASCULATURE ALTERATIONS IN ADULTS BORN PRETERM WITH VERY LOW BIRTH WEIGHT: A Birth Cohort Study.Retina (Philadelphia, Pa.) · 2025Article
- Review of Retinopathy of Prematurity Management in the Anti-VEGF Era: Evolving Global Paradigms, Persistent Challenges and Our AI-Assisted Future.Clinical & experimental ophthalmology · 2025Review
- Visualization of the Persistent Avascular Retina with Ultra-Widefield Green Reflectance Imaging.Diagnostics (Basel, Switzerland) · 2025Article
- Persistent avascular retina in retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- Investigation of the rates of retinopathy of prematurity and other diseases in infants born late preterm: is routine ROP examination required?Eye (London, England) · 2025Article
- Persistent neovascularization in regressed retinopathy of prematurity.Eye (London, England) · 2025Article
- Ultra-Widefield Optical Coherence Tomography Beyond the Ora Serrata in Retinopathy of Prematurity.JAMA ophthalmology · 2025Article
- A comparation of three different anti-VEGF drugs in development of persistent avascular retina in premature children.Scientific reports · 2024Article
- Innovative Use of Nanomaterials in Treating Retinopathy of Prematurity.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Surgical Outcomes of Rhegmatogenous Retinal Detachment Associated with Regressed Retinopathy of Prematurity.Turkish journal of ophthalmology · 2024Article
- Macular Curvature in Adults Born Preterm With and Without ROP: Results from the Gutenberg Prematurity Eye Study.Investigative ophthalmology & visual science · 2024Article
- Macular Thickness Is Associated with Persistent Avascular Retina in Patients with a History of Untreated Retinopathy of Prematurity.Ophthalmology. Retina · 2024Article
- Anterior chamber fluorescein leakage in a child with intraocular pressure elevation and vitreous hemorrhage.American journal of ophthalmology case reports · 2023Article
- Evaluation of retinal vascularization in retinopathy of prematurity regressed after intravitreal ranibizumab monotherapy or without treatment based on fluorescein angiography.Scientific reports · 2023Article
- Retinopathy of prematurity: from oxygen management to molecular manipulation.Molecular and cellular pediatrics · 2023Review
Corrections and comments
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Authors and funding
29 authors at 15 institutions in 1 country.
Funding
Abstract
purposeTo investigate late retinal findings and complications of eyes with a history of retinopathy of prematurity (ROP) that did not meet treatment criteria and did not receive treatment during infancy.
designRetrospective, nonconsecutive, noncomparative, multicenter case series.
participantsThree hundred sixty-three eyes of 186 patients.
methodsData were requested from multiple providers on premature patients with a history of ROP and no treatment during infancy who demonstrated late retinal findings or complications and included age, gender, gestational age and weight, zone and stage at infancy, visual acuity, current retina vascularization status, vitreous character, presence of peripheral retinal findings such as lattice retinal tears and detachments (RDs), retinoschisis, and fluorescein findings.
main outcome measuresRate of RDs and factors conferring a higher risk of RDs.
resultsThe average age was 34.5 years (range, 7-76 years), average gestational age was 26.6 weeks (range, 23-34 weeks), and average birth weight was 875 g (range, 425-1590 g). Findings included lattice in 196 eyes (54.0%), atrophic holes in 126 eyes (34.7%), retinal tears in 111 eyes (30.6%), RDs in 140 eyes (38.6 %), tractional retinoschisis in 44 eyes (11.9%), and visible vitreous condensation ridge-like interface in 112 eyes (30.5%). Fluorescein angiography (FA) was performed in 113 eyes, of which 59 eyes (52.2%) showed leakage and 16 eyes (14.2%) showed neovascularization. Incomplete vascularization posterior to zone 3 was common (71.6% of eyes). Retinal detachments were more likely in patients with a gestational age of 29 weeks or less (P < 0.05) and in eyes with furthest vascularization to posterior zone 2 eyes compared with zone 3 eyes (P = 0.009).
conclusionsEyes with ROP not meeting the treatment threshold during infancy showed various late retinal findings and complications, of which RDs were the most concerning. Complications were seen in all age groups, including patients born after the Early Treatment for Retinopathy of Prematurity Study. Contributing factors to RDs included atrophic holes within peripheral avascular retina, visible vitreous condensation ridge-like interface with residual traction, and premature vitreous syneresis. We recommend regular examinations and consideration of ultra-widefield FA examinations. Prospective studies are needed to explore the frequency of complications and benefit of prophylactic treatment and if eyes treated with anti-vascular endothelial growth factor therapy are at risk of similar findings and complications.
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