Evidence map›Paper›PMID 32059882›Full record

ArticleCarbohydrate polymers2020

Hypromellose acetate succinate based amorphous solid dispersions via hot melt extrusion: Effect of drug physicochemical properties.

Sandeep Sarabu, Venkata Raman Kallakunta, Suresh Bandari, Amol Batra, Vivian Bi, Thomas Durig, Feng Zhang, Michael A Repka

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion technique: Investigation of the formulation and process suitability.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2021
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sandeep SarabuDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi University, 38677, USA. Electronic address: ssarabu@go.olemiss.edu.
Venkata Raman KallakuntaDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi University, 38677, USA. Electronic address: vkallaku@go.olemiss.edu.
Suresh BandariDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi University, 38677, USA. Electronic address: sbandari@olemiss.edu.
Amol BatraAshland Specialty Ingredients, Wilmington, DE 19808, USA. Electronic address: amol_batra@ashland.com.
Vivian BiAshland Specialty Ingredients, Wilmington, DE 19808, USA. Electronic address: vbi@ashland.com.
Thomas DurigAshland Specialty Ingredients, Wilmington, DE 19808, USA. Electronic address: tdurig@ashland.com.
Feng ZhangCollege of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: feng.zhang@austin.utexas.edu.
Michael A RepkaDepartment of Pharmaceutics and Drug Delivery, The University of Mississippi University, 38677, USA; Pii Center for Pharmaceutical Innovation and Instruction, The University of Mississippi University 38677, USA. Electronic address: marepka@olemiss.edu.
University of Mississippi · USAshland (United States) · USThe University of Texas at Austin · US

Funding

Pilot Project ProgramP30GM122733 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI WILLETT, KRISTINE L · 2018 to 2022
$5.3M
NIGMS NIH HHS P30 GM122733
6 · The paper itself

Abstract

In this study, the impact of drug and hydroxypropyl methylcellulose acetate succinate (HPMCAS) grades physicochemical properties on extrusion process, dissolution and stability of the hot melt extruded amorphous solid dispersions (ASDs) of nifedipine and efavirenz was investigated. Incorporation of drugs affected the extrusion temperature required for solid dispersion preparation. Differential scanning calorimetry and powder X-ray diffraction studies confirmed the amorphous conversion of the drugs in the prepared formulations. The amorphous nature of ASDs was unchanged after 3 months of stability testing at 40 °C and 75% relative humidity. The dissolution efficiency of the ASDs was dependent on the log P of the drug. The inhibitory effect of HPMCAS on drug precipitation was dependent on the hydrophobic interactions between drug and polymer, polymer grade, and dose of the drug. The dissolution efficiency and dissolution rate of the ASDs were dependent on the log P of the drug and solubility and hydrophilicity of the polymer grade respectively. The inhibitory effect of HPMCAS on drug precipitation was dependent on the hydrophobic interactions between drug and polymer, polymer grade, and the dissolution dose of the drug.

Indexed as

AcetatesAlkynesBenzoxazinesCyclopropanesDrug CompoundingDrug LiberationDrug StabilityExcipientsHot Melt Extrusion TechnologyHot TemperatureHypromellose DerivativesMethylcelluloseNifedipineSolubilitySuccinatesAcetatesAlkynesBenzoxazinesCyclopropanesefavirenzExcipientshydroxypropylmethylcellulose acetate succinateHypromellose DerivativesMethylcelluloseNifedipineSuccinatesEfavirenzHMEHPMCASNifedipineSolid dispersionsSupersaturation

Identifiers

PMID32059882
PMCPMC7082948
OpenAlexW2999264118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.