Evidence map›Paper›PMID 32059838›Full record

ArticleProgress in cardiovascular diseases

Physical activity trends and metabolic health outcomes in people living with HIV in the US, 2008-2015.

Amanda L Willig, Allison R Webel, Andrew O Westfall, Emily B Levitan, Heidi M Crane, Thomas W Buford, Greer A Burkholder, James H Willig, Aaron J Blashill, Richard D Moore and 9 more

Abstract readMulticenter Study
In one paragraph

Article in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Amanda L WilligDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, United States of America. Electronic address: awillig@uabmc.edu.
Allison R WebelFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, United States of America.
Andrew O WestfallDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Emily B LevitanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Heidi M CraneDepartment of Medicine, Harborview Medical Center, University of Washington, Seattle, WA, United States of America.
Thomas W BufordDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Greer A BurkholderDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, United States of America.
James H WilligDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Aaron J BlashillDepartment of Psychology, San Diego State University, San Diego, CA, United States of America.
Richard D MooreJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
W Christopher MathewsDepartment of Medicine, University of California San Diego, San Diego, CA, United States of America.
Anne ZinskiDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Josh MuhammadDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, United States of America.
Elvin H GengSchool of Medicine, University of California, San Francisco, CA, United States of America.
Sonia NapravnikDepartment of Medicine, University of North Carolina, Chapel Hill, NC, United States of America.
Joseph J EronDepartments of Medicine and Epidemiology, University of North Carolina, Chapel Hill, NC, United States of America.
Benigno RodriguezDepartment of Medicine, Case Western Reserve University, Cleveland, OH, United States of America.
Marcas M BammanDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States of America.
E Turner OvertonDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, United States of America.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Links between Cardiovascular disease, Lung disease, and Obstructive sleep apnea in HIV: Understanding complex patientsR01HL126538 · NHLBI · UNIVERSITY OF WASHINGTON · PI CRANE, HEIDI M., CROTHERS, KRISTINA ANNE · 2015 to 2025
$5.1M
Impact of Physical Activity Routines and Dietary Intake on the Longitudinal Symptom Experience of the people living with HIV (PROSPER-HIV)R01NR018391 · NINR · UNIVERSITY OF WASHINGTON · PI WEBEL, ALLISON R · 2018 to 2022
$4.0M
UAB Center for Clinical and Translational Sciences (CCTS)TL1TR001418 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2018
$2.1M
NCATS NIH HHS TL1 TR001418NHLBI NIH HHS R01 HL126538NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027767NIAID NIH HHS P30 AI050410NIAID NIH HHS P30 AI094189NIAID NIH HHS R24 AI067039NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626NINR NIH HHS R01 NR018391
6 · The paper itself

Abstract

Despite its potential to improve metabolic health outcomes, longitudinal physical activity (PA) patterns and their association with cardiometabolic disease among people living with HIV (PLWH) have not been well characterized. We investigated this relationship among PLWH in the Centers for AIDS Research Network of Integrated Clinical Systems with at least one PA self-report between 2008 and 2015. The 4-item Lipid Research Clinics PA instrument was used to categorize habitual PA levels as: Very Low, Low, Moderate, or High. We analyzed demographic differences in PA patterns. Multivariable generalized estimating equation regression models were fit to assess longitudinal associations of PA with blood pressure, lipid, and glucose levels. Logistic regression modeling was used to assess the odds of being diagnosed with obesity, cardiovascular disease (CVD), cerebrovascular disease, hypertension, diabetes, or multimorbidity. A total of 40,462 unique PA assessments were provided by 11,719 participants. Only 13% of PLWH reported High PA, while 68% reported Very Low/Low PA at baseline and did not increase PA levels during the study period. Compared to those reporting High PA, participants with Very Low PA had almost 2-fold increased risk for CVD. Very Low PA was also associated with several risk factors associated with CVD, most notably elevated triglycerides (odds ratio 25.4), obesity (odds ratio 1.9), hypertension (odds ratio 1.4), and diabetes (odds ratio 2.3; all p < 0.01). Low levels of PA over time among PLWH are associated with increased cardiometabolic disease risk.

Indexed as

Anti-HIV AgentsCardiovascular DiseasesEnergy MetabolismExerciseHIV InfectionsHIV Long-Term SurvivorsMetabolic DiseasesBiomarkersFemaleHealth StatusHumansMaleProtective FactorsRetrospective StudiesRisk AssessmentRisk FactorsAnti-HIV AgentsBiomarkersCardiovascular diseaseDiabetesHealth disparitiesHealth outcomesMultimorbidityObesity

Identifiers

PMID32059838
PMCPMC7315582

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.