Evidence map›Paper›PMID 32059771›Full record

ArticleCurrent biology : CB2020

Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis.

Chih-Ying Lee, C Gaston Bisig, Michael M Conrad, Yanina Ditamo, Luciana Previato de Almeida, Michael E Dresser, Roberto J Pezza

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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  11. Diffusion and distal linkages govern interchromosomal dynamics during meiotic prophase.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chih-Ying LeeCell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA.
C Gaston BisigFacultad de Ciencias Químicas, Dpto. Química Biológica Ranwel Caputto-CIQUIBIC, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria de Córdoba, Córdoba X5000HUA, Argentina.
Michael M ConradCell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA.
Yanina DitamoFacultad de Ciencias Químicas, Dpto. Química Biológica Ranwel Caputto-CIQUIBIC, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria de Córdoba, Córdoba X5000HUA, Argentina.
Luciana Previato de AlmeidaCell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA.
Michael E DresserCell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA.
Roberto J PezzaCell Cycle and Cancer Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA; Department of Cell Biology, University of Oklahoma Health Science Center, 865 Research Parkway, Oklahoma City, OK 73104, USA. Electronic address: pezzar@omrf.org.
Oklahoma Medical Research Foundation · USResearch Centre in Biological Chemistry of Córdoba · ARUniversity of Oklahoma Health Sciences Center · US

Funding

Epigenetic control of meiotic recombination in mammals - Equipment SupplementR01GM125803 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI PEZZA, ROBERTO JOSE · 2018 to 2021
$1.8M
NIGMS NIH HHS R01 GM125803
6 · The paper itself

Abstract

Telomere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes required for successful haploidization of the genome. Critical components of the machinery that generates rapid prophase movements are unknown, and the mechanism underlying rapid prophase movements remains poorly understood. We identified S. cerevisiae Mps2 as the outer nuclear membrane protein that connects the LINC complex with the cytoskeleton. We also demonstrate that the motor Myo2 works together with Mps2 to couple the telomeres to the actin cytoskeleton. Further, we show that Csm4 interacts with Mps2 and is required for perinuclear localization of Myo2, implicating Csm4 as a regulator of the Mps2-Myo2 interaction. We propose a model in which the newly identified functions of Mps2 and Myo2 cooperate with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cytoskeleton.

Indexed as

Actin CytoskeletonChromosomes, FungalCytoskeletonMeiosisMembrane ProteinsMyosin Heavy ChainsMyosin Type VNuclear EnvelopeNuclear ProteinsProphaseSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTelomereCSM4 protein, S cerevisiaeMembrane ProteinsMPS2 protein, S cerevisiaeMYO2 protein, S cerevisiaeMyosin Heavy ChainsMyosin Type VNuclear ProteinsSaccharomyces cerevisiae ProteinsLINC complexlive imagingmeiosisnuclear envelopeS. cerevisiaetelomere-led rapid chromosome movementsyeast

Identifiers

PMID32059771
PMCPMC7181386
OpenAlexW3005918860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.