Evidence map›Paper›PMID 32059697›Full record

ReviewJournal of biomedical science2020

Better influenza vaccines: an industry perspective.

Juine-Ruey Chen, Yo-Min Liu, Yung-Chieh Tseng, Che Ma

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of biomedical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 136 citations in OpenAlex.

  1. Trial
  2. Article
  3. mRNA Vaccines for Influenza: Hope for a Universal Vaccine?BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
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  20. Co-injection with inactivatedFrontiers in microbiology · 2025
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Juine-Ruey ChenRuenHuei Biopharmaceuticals, Inc., Taipei, 100, Taiwan.
Yo-Min LiuGenomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
Yung-Chieh TsengGenomics Research Center, Academia Sinica, Taipei, 115, Taiwan.
Che MaGenomics Research Center, Academia Sinica, Taipei, 115, Taiwan. cma@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0002-4741-2307
Genomics Research Center, Academia Sinica · TWFountain Biopharma (Taiwan) · TWNational Yang Ming Chiao Tung University · TW

Funding

Academic Sinica Genomics Research Center Summit Project AS-SUMMIT-108
6 · The paper itself

Abstract

Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with extensive monitoring and annual reformulation our efforts remain one step behind the rapidly evolving virus, often resulting in mismatches and low vaccine effectiveness. Fortunately, many next-generation influenza vaccines are currently in development, utilizing an array of innovative techniques to shorten production time and increase the breadth of protection. This review summarizes the production methods of current vaccines, recent advances that have been made in influenza vaccine research, and highlights potential challenges that are yet to be overcome. Special emphasis is put on the potential role of glycoengineering in influenza vaccine development, and the advantages of removing the glycan shield on influenza surface antigens to increase vaccine immunogenicity. The potential for future development of these novel influenza vaccine candidates is discussed from an industry perspective.

Indexed as

Immunogenicity, VaccineProtein EngineeringGlycoproteinsGlycosylationHumansInfluenza VaccinesViral ProteinsGlycoproteinsInfluenza VaccinesViral ProteinsInfluenza virusMonoglycosylated HAMonoglycosylated split vaccineUniversal vaccine

Identifiers

PMID32059697
PMCPMC7023813
OpenAlexW3007714267

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.