ReviewGenome biology2020
Mutational signatures: experimental design and analytical framework.
Review in Genome biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- SigRescueR: a pan-system framework for noise correction and mutational signature identification across sequencing platforms.Briefings in bioinformatics · 2026Article
- Endogenous Processes Underlying Clock-Like Mutational Signatures.Genes, chromosomes & cancer · 2026Article
- A Universal Duplex Sequencing Approach for Accurate Detection of Somatic Mutations.bioRxiv : the preprint server for biology · 2025Article
- Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley rats.bioRxiv : the preprint server for biology · 2025Article
- Comprehensive analysis of mutational processes across 20 000 adult and pediatric tumors.Nucleic acids research · 2025Article
- The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.Nature genetics · 2024Article
- CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Aristolochic acid-associated cancers: a public health risk in need of global action.Nature reviews. Cancer · 2022Review
- The mutational signatures of formalin fixation on the human genome.Nature communications · 2022Article
- Electroporation of Small Interfering RNAs into Tibialis Anterior Muscles of Mice.Bio-protocol · 2022Article
- Therapeutic and prognostic insights from the analysis of cancer mutational signatures.Trends in genetics : TIG · 2022Review
- APOBEC-mediated mutagenesis is a favorable predictor of prognosis and immunotherapy for bladder cancer patients: evidence from pan-cancer analysis and multiple databases.Theranostics · 2022Article
- Mutations inNature cancer · 2021Article
- Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures.DNA repair · 2021Review
- Mutational signatures: emerging concepts, caveats and clinical applications.Nature reviews. Cancer · 2021Review
- FANCD2-Associated Nuclease 1 Partially Compensates for the Lack of Exonuclease 1 in Mismatch Repair.Molecular and cellular biology · 2021Article
- Mutational Signatures: From Methods to Mechanisms.Annual review of biomedical data science · 2021Article
- The genomes of precision edited cloned calves show no evidence for off-target events or increased de novo mutagenesis.BMC genomics · 2021Article
- Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.American journal of epidemiology · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures are underway. In this review, we highlight key aspects of mutational signature experimental design and describe the analytical framework. We suggest guidelines and quality control measures for handling whole-genome sequencing data for mutational signature analyses and discuss pitfalls in interpretation. We envision that improved next-generation sequencing technologies and molecular cell biology approaches will usher in the next generation of studies into the etiologies and mechanisms of mutational patterns uncovered in cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.