Evidence map›Paper›PMID 32059545›Full record

ArticleHigh-throughput2020

Rational Engineering of the Substrate Specificity of a Thermostable D-Hydantoinase (Dihydropyrimidinase).

Hovsep Aganyants, Pierre Weigel, Yeranuhi Hovhannisyan, Michèle Lecocq, Haykanush Koloyan, Artur Hambardzumyan, Anichka Hovsepyan, Jean-Noël Hallet, Vehary Sakanyan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in High-throughput, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hovsep AganyantsSPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, 0056 Yerevan, Armenia.
Pierre WeigelUFIP CNRS 6286, Faculté de Biologie, Université de Nantes, 44322 Nantes, France.
Yeranuhi HovhannisyanSPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, 0056 Yerevan, Armenia.
Michèle LecocqIICiMed, Faculté de Pharmacie, Université de Nantes, 44035 Nantes, France.
Haykanush KoloyanSPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, 0056 Yerevan, Armenia.
Artur HambardzumyanSPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, 0056 Yerevan, Armenia.
Anichka HovsepyanSPC Armbiotechnology, National Academy of Sciences of Republic of Armenia, 0056 Yerevan, Armenia.
Jean-Noël HalletUFIP CNRS 6286, Faculté de Biologie, Université de Nantes, 44322 Nantes, France.
Vehary SakanyanIICiMed, Faculté de Pharmacie, Université de Nantes, 44035 Nantes, France.
National Academy of Sciences of Armenia · AMCentre National de la Recherche Scientifique · FRCibles et Médicaments des Infections et de l'ImmunitéProtNeteomix (France) · FR

Funding

State Committee of Science 13-2I344State Committee of Science of the Ministry of Education and Science of the Republic of Armenia no. 13-2I344
6 · The paper itself

Abstract

D-hydantoinases catalyze an enantioselective opening of 5- and 6-membered cyclic structures and therefore can be used for the production of optically pure precursors for biomedical applications. The thermostable D-hydantoinase from

Indexed as

biocatalystD-hydantoinasedihydropyrimidinaselong inverse PCRmanganese-dependencesite-directed mutagenesissubstrate specificitythermophilic bacteria

Identifiers

PMID32059545
PMCPMC7175128
OpenAlexW3006316117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.