Evidence map›Paper›PMID 32059451›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones.

Zikai Feng, Jason A Smith, Nuri Gueven, Joselito P Quirino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zikai FengAustralian Centre for Research on Separation Sciences (ACROSS), School of Natural Sciences-Chemistry, College of Science and Engineering, University of Tasmania, Hobart TAS 7000, Australia.
Jason A SmithSchool of Natural Sciences-Chemistry, College of Science and Engineering, University of Tasmania, Hobart TAS 7000, Australia.
Nuri GuevenDivision of Pharmacy, School of Medicine, College of Health and Medicine, University of Tasmania, Hobart TAS 7000, Australia.
Joselito P QuirinoAustralian Centre for Research on Separation Sciences (ACROSS), School of Natural Sciences-Chemistry, College of Science and Engineering, University of Tasmania, Hobart TAS 7000, Australia.
University of Tasmania · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short-chain quinones (SCQs) have been identified as potential drug candidates against mitochondrial dysfunction, which is largely dependent on their reversible redox characteristics of the active quinone core. We recently synthesized a SCQ library of > 148 naphthoquinone derivatives and identified 16 compounds with enhanced cytoprotection compared to the clinically used benzoquinone idebenone. One of the major drawbacks of idebenone is its high metabolic conversion in the liver, which significantly restricts is therapeutic activity. Therefore, this study assessed the metabolic stability of the 16 identified naphthoquinone derivatives

Indexed as

HepG2 cell cultureidebenonemetabolic stabilitymitochondrial dysfunctionreverse-phase liquid chromatographyshort-chain quinone

Identifiers

PMID32059451
PMCPMC7169385
OpenAlexW2991963737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.