ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020
Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of NMDA-receptor blockade by ketamine on mentalizing and its neural correlates in humans: a randomized control trial.Scientific reports · 2023Trial
- Facial Emotion Recognition and its Associations With Psychological Well-Being Across Four Schizotypal Dimensions: a Cross-Sectional Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- How to elicit a negative bias? Manipulating contrast and saturation with the facial emotion salience task.Frontiers in psychology · 2024Article
- Cognitive Processes and Resting-State Functional Neuroimaging Findings in High Schizotypal Individuals and Schizotypal Personality Disorder Patients: A Systematic Review.Brain sciences · 2023Review
- Mind your step: social cerebellum in interactive navigation.Social cognitive and affective neuroscience · 2023Article
- Psychopathic and autistic traits differentially influence the neural mechanisms of social cognition from communication signals.Translational psychiatry · 2022Article
- Increased child-evoked activation in the precuneus during facial affect recognition in mothers.Human brain mapping · 2022Article
- Motherhood and theory of mind: increased activation in the posterior cingulate cortex and insulae.Social cognitive and affective neuroscience · 2022Article
- Eye Direction Detection and Perception as Premises of a Social Brain: A Narrative Review of Behavioral and Neural Data.Cognitive, affective & behavioral neuroscience · 2022Review
- Schizotypy and psychopathic tendencies interactively improve misattribution of affect in boys with conduct problems.European child & adolescent psychiatry · 2021Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Deficits in social cognition have been proposed as a marker of schizophrenia. Growing evidence suggests especially hyperfunctioning of the right posterior superior temporal sulcus (pSTS) in response to neutral social stimuli reflecting the neural correlates of social-cognitive impairments in schizophrenia. We characterized healthy participants according to schizotypy (n = 74) and the single-nucleotide polymorphism rs1344706 in ZNF804A (n = 73), as they represent risk variants for schizophrenia from the perspectives of personality traits and genetics, respectively. A social-cognitive fMRI task was applied to investigate the association of right pSTS hyperfunctioning in response to neutral face stimuli with schizotypy and rs1344706. Higher right pSTS activation in response to neutral facial expressions was found in individuals with increased positive (trend) and disorganization symptoms, as well as in carriers of the risk allele of rs1344706. In addition, a positive association between right-left pSTS connectivity and disorganization symptoms during neutral face processing was revealed. Although these findings warrant replication, we suggest that right pSTS hyperfunctioning in response to neutral facial expressions presents an endophenotype of schizophrenia. We assume that right pSTS hyperfunctioning is a vulnerability to perceive neutral social stimuli as emotionally or intentionally salient, probably contributing to the emergence of symptoms of schizophrenia.
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