ArticleAngewandte Chemie (International ed. in English)2020
Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Size.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 93 citations in OpenAlex.
- Metal-Organic Framework-Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Direct Synthesis of High-Valence Protein@UiO-66 Composites: Linking Crystallization Pathways to Protein Encapsulation.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Biomacromolecule-MOF Composites for Intracellular Delivery: From Empirical Construction to Rational Design and AI-Assisted Screening.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Advancements in Bimetallic Metal-Organic Frameworks for Oral Medicine.International dental journal · 2026Review
- ZIF-8 Nanodrug Delivery Systems: Construction Strategies, Functional Modifications, and Advances in Synergistic Tumor Therapy.International journal of nanomedicine · 2026Review
- Channel-Directed Enzymatic Depolymerization within a Metal-Organic Framework.ACS applied materials & interfaces · 2025Article
- Trifunctional Sialylation-Based SF-ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone-Vessel Regeneration in Osteoporotic Bone Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Ultrafast synthesis of zirconium-porphyrin framework nanocrystals from alkoxide precursors.Cell reports. Physical science · 2024Article
- A scalable synthesis of adjuvanting antigen depots based on metal-organic frameworks.Chemical science · 2024Article
- Water sensitivity of heteroepitaxial Cu-MOF films: dissolution and re-crystallization of 3D-oriented MOF superstructures.Chemical science · 2023Article
- Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy.Materials today. Bio · 2023Article
- Bioinspired Framework Catalysts: From Enzyme Immobilization to Biomimetic Catalysis.Chemical reviews · 2023Review
- Interrogating Encapsulated Protein Structure within Metal-Organic Frameworks at Elevated Temperature.Journal of the American Chemical Society · 2023Article
- Biomimetic Mineralization of Iron-Fumarate Nanoparticles for Protective Encapsulation and Intracellular Delivery of Proteins.Chemistry of materials : a publication of the American Chemical Society · 2022Article
- One-Pot Synthesis of HRP&SA/ZIF-8 Nanocomposite and Its Application in the Detection of Insecticidal Crystalline Protein Cry1Ab.Nanomaterials (Basel, Switzerland) · 2022Article
- Recent advances in nanoarchitectures of monocrystalline coordination polymers through confined assembly.Beilstein journal of nanotechnology · 2022Review
- Stabilization of supramolecular membrane protein-lipid bilayer assemblies through immobilization in a crystalline exoskeleton.Nature communications · 2021Article
- Coordination-based self-assembled capsules (SACs) for protein, CRISPR-Cas9, DNA and RNA delivery.Chemical science · 2021Review
- Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Size.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zeolitic imidazolate framework (ZIF) biocomposites show the capacity to protect and deliver biotherapeutics. To date, the progress in this research area is based on laboratory batch methods. Now, the first continuous flow synthetic method is presented for the encapsulation of a model protein (bovine serum albumin, BSA) and a clinical therapeutic (α1-antitrypsin, AAT) in ZIF-8. The in situ kinetics of nucleation, growth, and crystallization of BSA@ZIF-8 were studied by small-angle X-ray scattering. By controlling the injection time of ethanol, the particle growth could be quenched by ethanol-induced crystallization from amorphous particles to ZIF-8 crystals. The particle size of the biocomposite was tuned in the 40-100 nm range by varying residence time prior to introduction of ethanol. As a proof-of-concept, this procedure was used for the encapsulation of AAT in ZIF-8. Upon release of the biotherapeutic from the composite, the trypsin inhibitor function of AAT was preserved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.