ArticlePLoS genetics2020
Identifying neural substrates of competitive interactions and sequence transitions during mechanosensory responses in Drosophila.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A positive feedback loop between sensory and octopaminergic neurons underlies nociceptive plasticity in Drosophila larvae.PLoS genetics · 2026Article
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- Feeding state-dependent neuropeptidergic modulation of reciprocally interconnected inhibitory neurons biases sensorimotor decisions in Drosophila.Nature communications · 2025Article
- Article
- Neural substrates of cold nociception ineLife · 2025Article
- Statistical signature of subtle behavioral changes in large-scale assays.PLoS computational biology · 2025Article
- Neural circuits underlying context-dependent competition between defensive actions in Drosophila larvae.Nature communications · 2025Article
- Characterizing stage-dependent neuromotor patterns inFrontiers in neuroscience · 2025Article
- Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior ineLife · 2024Article
- LarvaTagger: manual and automatic tagging of Drosophila larval behaviour.Bioinformatics (Oxford, England) · 2024Article
- The connectome of an insect brain.Science (New York, N.Y.) · 2023Article
- Linking neural circuits to the mechanics of animal behavior inFrontiers in neural circuits · 2023Review
- Nociception in fruit fly larvae.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Article
- Computational model predicts the neural mechanisms of prepulse inhibition in Drosophila larvae.Scientific reports · 2022Article
- Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception.Frontiers in molecular neuroscience · 2022Article
- New Approach to Accelerated Image Annotation by Leveraging Virtual Reality and Cloud Computing.Frontiers in bioinformatics · 2021Article
- Useful road maps: studying Drosophila larva's central nervous system with the help of connectomics.Current opinion in neurobiology · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Nervous systems have the ability to select appropriate actions and action sequences in response to sensory cues. The circuit mechanisms by which nervous systems achieve choice, stability and transitions between behaviors are still incompletely understood. To identify neurons and brain areas involved in controlling these processes, we combined a large-scale neuronal inactivation screen with automated action detection in response to a mechanosensory cue in Drosophila larva. We analyzed behaviors from 2.9x105 larvae and identified 66 candidate lines for mechanosensory responses out of which 25 for competitive interactions between actions. We further characterize in detail the neurons in these lines and analyzed their connectivity using electron microscopy. We found the neurons in the mechanosensory network are located in different regions of the nervous system consistent with a distributed model of sensorimotor decision-making. These findings provide the basis for understanding how selection and transition between behaviors are controlled by the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.