ArticlePloS one2020
Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Review
- Intravenous paracetamol does not have significant opioid-sparing effects when used as part of a multimodal analgesic protocol in dogs undergoing elective orthopaedic surgery.The Veterinary record · 2026Article
- Perioperative analgesia and clinical safety of dexketoprofen in dogs undergoing ovariohysterectomy.Open veterinary journal · 2026Article
- Multimodal Analgesia Provides Superior Postoperative Pain Control Following Orthopedic Surgery in Small-Breed Dogs.Animals : an open access journal from MDPI · 2026Article
- Intraoperative magnesium sulphate as an analgesic adjunct in a multimodal, opioid-sparing protocol for canine ovariohysterectomy: a prospective, randomized, controlled, double-blind study.Frontiers in veterinary science · 2026Article
- Transcutaneous electrical nerve stimulation as an adjuvant treatment for thoracolumbar acute hyperesthesia in chondrodystrophic dogs: a prospective blinded controlled clinical study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Development of a novel intramuscular liposomal injection for advanced meloxicam delivery: Preparation, characterization,International journal of pharmaceutics: X · 2024Article
- Pain Management in Animals with Oncological Disease: Opioids as Influencers of Immune and Tumor Cellular Balance.Cancers · 2024Review
- Comparison between Carprofen and Meloxicam for Post-Neutering Pain Management in Pet Rabbits.Veterinary sciences · 2024Article
- Subcutaneous and orally self-administered high-dose carprofen shows favorable pharmacokinetic and tolerability profiles in male and female C57BL/6J mice.Frontiers in veterinary science · 2024Article
- Assessment of the nociceptive response to the use of cannabidiol alone and in combination with meloxicam through infrared pupillometry in female dogs undergoing elective ovariohysterectomy.Frontiers in veterinary science · 2024Article
- Cardiorespiratory Effects and Desflurane Requirement in Dogs Undergoing Ovariectomy after Administration Maropitant or Methadone.Animals : an open access journal from MDPI · 2023Article
- Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation.Scientific reports · 2023Article
- Premedication with acetazolamide: Is its use for postoperative pain and stress control after laparoscopic ovariectomy in dogs ruled out?Veterinary medicine and science · 2023Article
- Management of Osteoarthritis and Joint Support Using Feed Supplements: A Scoping Review of Undenatured Type II Collagen andAnimals : an open access journal from MDPI · 2023Article
- Comparison of radiographic scoring systems for assessment of bone healing after tibial plateau leveling osteotomy in dogs.Frontiers in veterinary science · 2023Article
- Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses.Animals : an open access journal from MDPI · 2022Review
- Thoracolumbar retrolaminar block in seven dogs undergoing spinal surgery.Irish veterinary journal · 2022Article
- Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs.Journal of veterinary pharmacology and therapeutics · 2022Article
- Laparoscopic versus Open Ovariectomy in Bitches: Changes in Cardiorespiratory Values, Blood Parameters, and Sevoflurane Requirements Associated with the Surgical Technique.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn veterinary medicine, the administration of nonsteroidal anti-inflammatory analgesics (NSAIDs) for the control of postsurgical pain in dogs and cats is common given the anti-inflammatory, analgesic, and antipyretic effects of these drugs. This study compared the serum biochemical changes and postoperative analgesic effects of paracetamol, meloxicam, and carprofen in bitches submitted to an ovariohysterectomy using the Dynamic Interactive Visual Analog Scale (DIVAS) and Pain Scale of the University of Melbourne (UMPS) scoring systems.
methodsThirty bitches of different breeds underwent elective ovariohysterectomies and were randomly assigned to one of three treatment groups: a paracetamol group [15 mg kg-1 intravenous (IV)], a carprofen group (4 mg kg-1 IV), and a meloxicam group (0.2 mg kg-1 IV). All treatments were administered 30 minutes prior to surgery. Paracetamol was administered every 8 hours postoperatively for 48 hours total, while carprofen and meloxicam were intravenously administered every 24 hours. An evaluation of post-surgical pain was done with the DIVAS and the UMPS. The first post-surgical pain measurement was performed 1 hour after surgery and then 2, 4, 6, 8, 12, 16, 20, 24, 36, and 48 hours after surgery.
resultsAll groups exhibited a gradual reduction in pain throughout the postoperative period in both scales; however, neither scale significantly differed between the three treatment groups (P > 0.05) during the 48 postoperative hours.
conclusionsParacetamol was as effective as meloxicam and carprofen for post-surgical analgesia in bitches subjected to elective ovariohysterectomy. The present study demonstrates that paracetamol may be considered a tool for the effective treatment of acute perioperative pain in dogs. Furthermore, this drug led to no adverse reactions or changes in the parameters assessed in the present study, indicating its safety.
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