Evidence map›Paper›PMID 32058811›Full record

ArticleAmerican journal on intellectual and developmental disabilities2020

Neurogenesis, Myelination, and Circuitry: The Case for a Distributed Therapeutic Regimen in Down Syndrome.

Tarik F Haydar

Open access · greenAbstract read
In one paragraph

Article in American journal on intellectual and developmental disabilities, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Tarik F HaydarTarik F. Haydar, Boston University School of Medicine.
Boston University · US

Funding

Mechanisms of White Matter Development in Down SyndromeR01NS105138 · NINDS · CHILDREN'S RESEARCH INSTITUTE · PI HAYDAR, TARIK F, VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2018 to 2022
$3.8M
Development of myelinating oligodendrocytes in Down syndromeR21HD098542 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZELDICH, ELLA · 2019 to 2020
$454k
Altered development and function of the spinal cord in Down syndromeR21NS095340 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAYDAR, TARIK F · 2016 to 2017
$452k
NICHD NIH HHS R21 HD098542NINDS NIH HHS R01 NS105138NINDS NIH HHS R21 NS095340
6 · The paper itself

Abstract

One of the overriding hopes of the Down syndrome (DS) research community is to arrive at a better understanding of how trisomy 21 affects brain development and function, and that doing so will improve quality of life and independence for people with DS. In searching for the underlying causes of intellectual disability in DS, researchers and clinicians have studied how changes to genes and cells may relate to motor and cognitive function. Thus far, alterations in many areas of the central nervous system have been found and it is now known that, beginning before birth, different changes occur in different areas over the course of life. Because of these spatial and temporal variations, multiple approaches for addressing motor and cognitive function must be considered.

Indexed as

BrainNerve NetDown SyndromeFetal DevelopmentHuman DevelopmentHumansMyelin SheathNeurogenesisAlzheimer's diseasebrain developmenttrisomy

Identifiers

PMID32058811
PMCPMC8265276
OpenAlexW3005645326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.