ArticleBrain and behavior2020
Surgical histopathologic findings of 232 Chinese children cases with drug-resistant seizures.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Integrated Multi-Omics Profiling Identifies CD84-Associated Microglial Alterations in Focal Cortical Dysplasia Type II.Journal of inflammation research · 2026Article
- Presurgical Characteristics and Seizure Outcomes in Patients With Focal Cortical Dysplasia Type I, II, and III: A Single-Center Study.Brain and behavior · 2025Article
- Focal cortical dysplasia type II: review of neuropathological manifestations and pathogenetic mechanisms.Acta epileptologica · 2025Review
- An Assessment of the Pathological Classification and Postoperative Outcome of Focal Cortical Dysplasia by Simultaneous Hybrid PET/MRI.Brain sciences · 2023Article
- Developing a deep learning model to predict epilepsy recurrence in patients with focal cortical dysplasia type III.Quantitative imaging in medicine and surgery · 2023Article
- Pathogenesis and Therapeutic Targets of Focal Cortical Dysplasia Based on Bioinformatics Analysis.Neurochemical research · 2022Article
- Pathological Networks Involving Dysmorphic Neurons in Type II Focal Cortical Dysplasia.Neuroscience bulletin · 2022Article
- Focal Cortical Dysplasia Type Ⅲ Related Medically Refractory Epilepsy: MRI Findings and Potential Predictors of Surgery Outcome.Diagnostics (Basel, Switzerland) · 2021Article
- Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.International journal of biological sciences · 2021Article
- Preliminary analysis of the effect of vagus nerve stimulation in the treatment of children with intractable epilepsy.World journal of clinical cases · 2020Article
- Surgical histopathologic findings of 232 Chinese children cases with drug-resistant seizures.Brain and behavior · 2020Article
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6 authors.
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Abstract
objectivesThe drug-resistant seizures are characterized by frequent and severe onset of seizures in childhood. There is only little literature had extensively explored the types of pathological brain damage in Chinese children cases. The present study aims to investigate the histopathologic findings and seizure outcomes of drug-resistant seizures in cases of 0-14-year-old children. MATERIALS AND
methodsAbout 232 children cases were retrospectively who underwent epilepsy surgery. The medical records, onset age, age of surgery, disease course, seizure type, pathological reports, and seizure outcomes of these patients were retrospectively analyzed.
resultsThe most common categories were malformations of cortical development (focal cortical dysplasia (FCD) was the most common type (94.36%, 67/71), found in 30.60% of the patients, tumors in 18.11%, glial scar in 12.50%, and encephalitis in 11.63%). It was found that the effective seizure outcome of FCD cases with shorter duration of epilepsy (<2 years, 87.23%) was better than that with longer duration (≥2 years, 60.00%) and the difference was statistically significant (χ
conclusionThe malformations of cortical development (MCD) (most FCD) were the most common pathological type for children cases in China with drug-resistant seizures. It was speculated further that the FCD patients with shorter duration of epilepsy before surgery seem to have a higher ratio of being seizure-free after surgery.
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