ArticleEuropean heart journal. Cardiovascular pharmacotherapy2021
Low adherence to statin treatment during the 1st year after an acute myocardial infarction is associated with increased 2nd-year mortality risk-an inverse probability of treatment weighted study on 54 872 patients.
Article in European heart journal. Cardiovascular pharmacotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Adherence to Lipid-Lowering Therapies and Cardiovascular Outcomes in Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025 · on this mapPooled it
- Trial
- Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease: the MIMeRiC randomized controlled trial.BMC cardiovascular disorders · 2021Trial
- Impact of the fibrosis-4 index on postoperative complications in patients undergoing laparoscopic liver resection.Surgical endoscopy · 2026Article
- Lipid-Lowering Treatment in Familial Hypercholesterolaemia, 1996-2021: A Nationwide Study.The Lancet regional health. Europe · 2026Article
- Review
- Efficacy and safety of combination therapy with statin and ezetimibe in patients failing to achieve target LDL levels at cardiology outpatient clinics in Turkey (COM-TR-OLDL): a real-world observational study.Lipids in health and disease · 2026Observational
- Higher Arterial Oxygen Levels Associated with Improved Survival in Neurocritically Ill Brain Tumor Patients.Journal of Korean Neurosurgical Society · 2026Article
- Mortality comparison in acute myocardial infarction patients according to presence versus absence of traditional modifiable cardiovascular risk factors.Bioinformation · 2026Article
- Molecular and Immunomodulatory Mechanisms of Statins in Inflammation and Cancer Therapeutics with Emphasis on the NF-κB, NLRP3 Inflammasome, and Cytokine Regulatory Axes.International journal of molecular sciences · 2025Review
- Cardiovascular Nursing in Rehabilitative Cardiology: A Review.Journal of cardiovascular development and disease · 2025Review
- Prescription Refill Adherence Before and After Patient Portal Registration in Among General Practice Patients in England Using the Clinical Practice Research Datalink: Longitudinal Observational Study.JMIR medical informatics · 2025Observational
- Adherence to secondary preventive treatment following myocardial infarction with and without obstructive coronary artery disease.PloS one · 2025Observational
- Article
- Recognition of language barriers in comprehending non-communicable disease management among rural elderly people in the DIMAMO surveillance area: a case of AWI-Gen participants.BMC public health · 2024Article
- The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia.Frontiers in endocrinology · 2024Observational
- A retrospective nationwide analysis of evolocumab use in Sweden and its effect on low-density lipoprotein cholesterol levels.Upsala journal of medical sciences · 2024Article
- Intensive nurse-led follow-up in primary care to improve self-management and compliance behaviour after myocardial infarction.Nursing open · 2023Article
- Association between Fibrinogen-to-Albumin Ratio and Prognosis in Patients Admitted to an Intensive Care Unit.Journal of clinical medicine · 2023Article
- Impact of early nutrition and feeding route on clinical outcomes of neurocritically ill patients.PloS one · 2023Observational
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsExperiencing an acute myocardial infarction (AMI) is a life-threatening event and use of statins can reduce the probability of recurrence and improve long-term survival. However, the effectiveness of statins in the real-world setting may be lower than the reported efficacy in randomized clinical trials. Therefore, we aimed to investigate whether low statin treatment adherence during the year following an AMI episode is associated with increased 2nd-year mortality. METHODS AND
resultsWe analysed all 54 872 AMI patients aged ≥45 years, admitted to Swedish hospitals between 2010 and 2012, and who survive at least 1 year after the AMI episode. We defined low adherence as a medication possession ratio <50% or non-use of statins. Applying inverse probability of treatment weighting (IPTW), we investigated the association between low adherence and all-cause, cardiovascular disease (CVD), and non-CVD mortality during the 2nd year. Overall, 20% of the patients had low adherence during the 1st year and 8% died during the 2nd year. In the IPTW analysis, low adherence was associated with an increased risk of all-cause [absolute risk difference (ARD) = 0.048, number needed to harm (NNH) = 21, relative risk (RR) = 1.71], CVD (ARD = 0.035, NNH = 29, RR = 1.62), and non-CVD mortality (ARD = 0.013, NNH = 77, RR = 2.17).
conclusionIn the real-world setting, low statin adherence during the 1st year after an AMI episode is associated with increased mortality during the 2nd year. Our results reaffirm the importance of achieving a high adherence to statin treatment after suffering from an AMI.
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