Evidence map›Paper›PMID 32058245›Full record

ArticleDrug and alcohol dependence2020

Making pharmacotherapy trials for substance use disorder more efficient: Leveraging real-world data capture to maximize power and expedite the medication development pipeline.

Ryan W Carpenter, Lindsay M Squeglia, Noah N Emery, Erin A McClure, Kevin M Gray, Robert Miranda, Rachel L Tomko

Abstract readLetter
In one paragraph

Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  2. Trial
  3. Trial
  4. Trial
  5. Day-level shifts in social contexts during youth cannabis use treatment.Journal of consulting and clinical psychology · 2021
    Trial
  6. Article
  7. Use and co-use of alcohol and cannabis following physical pain in the daily life of community adults engaged in regular substance use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan W CarpenterDepartment of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, United States. Electronic address: ryan_carpenter@brown.edu.
Lindsay M SquegliaDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, United States.
Noah N EmeryDepartment of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, United States.
Erin A McClureDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, United States.
Kevin M GrayDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, United States.
Robert MirandaDepartment of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, United States.
Rachel L TomkoDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, United States.

Funding

Southern Consortium Node of the Clinical Trials Network (Varenicline)UG1DA013727 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KATHLEEN T. BRADY, Kelly S. Barth · 2015 to 2026
$24.8M
Vocational Training for Drug Dependent WomenP50DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2002 to 2017
$14.5M
ALCOHOL INTERVENTION/TREATMENT OUTCOME RESEARCH TRAININGT32AA007459 · NIAAA · BROWN UNIVERSITY · PI ROBERT MIRANDA, PETER M. MONTI · 1986 to 2026
$13.3M
Interdisciplinary Women's Health Research at MUSCK12HD055885 · NICHD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCGINTY, JACQUELINE F. · 2007 to 2021
$7.2M
Substance Abuse Intervention/Outcome Research TrainingT32DA016184 · NIDA · BROWN UNIVERSITY · PI Damaris J. Rohsenow, JENNIFER W. TIDEY · 2003 to 2026
$6.1M
A Proof-of-Concept Trial of N-Acetylcysteine for Adolescent Alcohol Use DisorderR01AA027399 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAY, KEVIN M, SQUEGLIA, LINDSAY · 2018 to 2022
$3.5M
N-Acetylcysteine and Contingency Management for Youth Cannabis Use DisorderR01DA042114 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GRAY, KEVIN M · 2017 to 2021
$3.1M
Mentored Patient-Oriented Research on Adolescent Alcohol Misuse and TreatmentK24AA026326 · NIAAA · BROWN UNIVERSITY · PI ROBERT MIRANDA · 2018 to 2026
$1.7M
Neuroscience-informed Treatment Development for Adolescent Alcohol Use DisordersK23AA025399 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SQUEGLIA, LINDSAY · 2016 to 2020
$1.0M
Evaluating N-acetylcysteine as a pharmacotherapy for tobacco use disorderR34DA042228 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCCLURE, ERIN A · 2016 to 2018
$660k
NIAAA NIH HHS K23 AA025399NIAAA NIH HHS K24 AA026326NIAAA NIH HHS R01 AA027399NIAAA NIH HHS T32 AA007459NICHD NIH HHS K12 HD055885NIDA NIH HHS P50 DA016511NIDA NIH HHS R01 DA042114NIDA NIH HHS R34 DA042228NIDA NIH HHS T32 DA016184NIDA NIH HHS UG1 DA013727
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID32058245
PMCPMC7138753

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.