Evidence map›Paper›PMID 32058243›Full record

ArticleDrug and alcohol dependence2020

Alcohol expectancies mediate the association between the neural response to emotional words and alcohol consumption.

Sarah J Brislin, Jillian E Hardee, Meghan E Martz, Lora M Cope, Alexander Weigard, Robert A Zucker, Mary M Heitzeg

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarah J BrislinUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA.
Jillian E HardeeUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA.
Meghan E MartzUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA.
Lora M CopeUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA.
Alexander WeigardUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA.
Robert A ZuckerUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA.
Mary M HeitzegUniversity of Michigan, Department of Psychiatry and Addiction Center, 4250 Plymouth Road Ann Arbor, MI 48109, USA. Electronic address: mheitzeg@med.umich.edu.
University of Michigan–Ann Arbor · US

Funding

MULTIDISCIPLINARY ALCOHOLISM RESEARCH TRAINING PROGRAMT32AA007477 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maureen A. Walton · 1990 to 2026
$7.4M
RISK AND COPING IN CHILDREN OF ALCOHOLICSR01AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M · 1987 to 2017
$6.1M
Developmental neurobiological and contextual influences on alcohol use disorderR01AA025790 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M, HICKS, BRIAN M · 2018 to 2022
$2.8M
Multi-method signature of risk for compulsive substance use: Human translation of the incentive-sensitization modelK01DA044270 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COPE, LORA M. · 2019 to 2023
$835k
Sex differences in the neural mechanisms of brief interventions for binge drinkingK01AA024804 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARDEE, JILLIAN ELIZABETH · 2016 to 2020
$830k
Developmental and sex differences in modulation of nucleus accumbens activationK01AA027558 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTZ, MEGHAN ELIZABETH · 2019 to 2023
$826k
NIAAA NIH HHS K01 AA024804NIAAA NIH HHS K01 AA027558NIAAA NIH HHS R01 AA007065NIAAA NIH HHS R01 AA025790NIAAA NIH HHS T32 AA007477NIDA NIH HHS K01 DA044270
6 · The paper itself

Abstract

backgroundBoth positive expectancies regarding the effects of alcohol and internalizing problems, including negative emotionality and deficits in emotion regulation, are known risk factors for alcohol use disorder (AUD). The current study is the first to investigate how neural response to emotional stimuli may impact alcohol expectancies and risk for AUD.

methodsFunctional neuroimaging data was collected during an emotional word task from 168 emerging adults (M age = 19.65; 66% male). Activation to negative versus neutral words and positive versus neutral words was extracted for analyses. Participants also reported on their alcohol expectancies and information regarding alcohol use and problems was collected prospectively throughout adolescence and into adulthood (up to age 30).

resultsDecreased activation in the inferior frontal gyrus (IFG) to negative versus neutral words was associated with increased post-scan alcohol consumption, measured as average drinks per year. There was a significant indirect effect of positive alcohol expectancies on the association between IFG activation and post-scan alcohol consumption, even when controlling for quantity of alcohol consumption prior to the scan.

conclusionsThese results are the first to provide evidence that positive alcohol expectancies account for variance shared between brain regions associated with emotion processing and increased drinking behaviors. Alcohol expectancies may provide a modifiable target for treatments to decrease the link between deficits in emotion regulation and increased alcohol use.

Indexed as

AdolescentAlcohol DrinkingAnticipation, PsychologicalBrainEmotionsFemaleHumansLongitudinal StudiesMalePhotic StimulationSurveys and QuestionnairesWord Association TestsYoung AdultAlcoholEmotionfMRIPositive alcohol expectancies

Identifiers

PMID32058243
PMCPMC7357240
OpenAlexW3004665186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.