Evidence map›Paper›PMID 32058043›Full record

ArticleProgress in neurobiology2020

Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation.

Mahesh M Karnani, Cornelia Schöne, Edward F Bracey, J Antonio González, Paulius Viskaitis, Han-Tao Li, Antoine Adamantidis, Denis Burdakov

Abstract read
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In one paragraph

Article in Progress in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  17. Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mahesh M KarnaniDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; The Francis Crick Institute, London, UK; Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. Electronic address: mahesh.karnani@hest.ethz.ch.
Cornelia SchöneThe Francis Crick Institute, London, UK; Systems Neuroscience, University of Göttingen, Germany.
Edward F BraceyDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; The Francis Crick Institute, London, UK.
J Antonio GonzálezThe Francis Crick Institute, London, UK; The Rowett Institute, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, UK.
Paulius ViskaitisDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.
Han-Tao LiDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland.
Antoine AdamantidisDepartment of Neurology, Inselspital, University of Bern, Switzerland; Department of Biomedical Research, University of Bern, Switzerland.
Denis BurdakovDepartment of Health Sciences and Technology, ETH Zürich, Zürich, Switzerland; The Francis Crick Institute, London, UK; Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK; Neuroscience Center Zürich (ZNZ), ETH Zürich and University of Zürich, Zürich, Switzerland.

Funding

Cancer Research UK FC001055Medical Research Council FC001055Wellcome Trust FC001055
6 · The paper itself

Abstract

Appropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display rapid (subsecond) activity fluctuations in vivo. The necessity of these activity bursts for sensorimotor control and their roles in specific phases of movement are unknown. Here we show that temporally-restricted optosilencing of spontaneous or sensory-evoked HON bursts disrupts locomotion initiation, but does not affect ongoing locomotion. Conversely, HON optostimulation initiates locomotion with subsecond delays in a frequency-dependent manner. Using 2-photon volumetric imaging of activity of >300 HONs during sensory stimulation and self-initiated locomotion, we identify several locomotion-related HON subtypes, which distinctly predict the probability of imminent locomotion initiation, display distinct sensory responses, and are differentially modulated by food deprivation. By causally linking HON bursts to locomotion initiation, these findings reveal the sensorimotor importance of rapid spontaneous and evoked fluctuations in HON ensemble activity.

Indexed as

AnimalsFemaleHypothalamusLocomotionMaleMiceMice, Inbred C57BLNeuronsOrexinsOrexinsEnsemble imagingHypothalamusLocomotionorexin/hypocretin neuronsSensorimotor processing

Identifiers

PMID32058043
PMCPMC7086232

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.