ArticleInternational journal of biological macromolecules2020
S-adenosylmethionine synthases in plants: Structural characterization of type I and II isoenzymes from Arabidopsis thaliana and Medicago truncatula.
Article in International journal of biological macromolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 58 citations in OpenAlex.
- A bHLH121/URI-ANAC017-MAT1/SAM1 regulatory cascade controls iron homeostasis in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Pollen-expressed methionine synthases in Nicotiana tabacum regulate pollen development and germination.Plant physiology · 2026Article
- Genome-wide identification and functional analysis of the SAMS gene family in peanut reveal the role of Ah6Q1KS5 in resistance to bacterial wilt.BMC plant biology · 2026Article
- Artificial Biopolymers Derived from Transgenic Plants: Applications and Properties-A Review.International journal of molecular sciences · 2024Review
- Effects of Selenium Content on Growth, Antioxidant Activity, and Key Selenium-Enriched Gene Expression in Alfalfa Sprouts.Foods (Basel, Switzerland) · 2024Article
- Metabolome and Transcriptome Association Analysis Reveals Mechanism of Synthesis of Nutrient Composition in Quinoa (Foods (Basel, Switzerland) · 2024Article
- Whole genome identification, molecular docking and expression analysis of enzymes involved in the selenomethionine cycle in Cardamine hupingshanensis.BMC plant biology · 2024Article
- Integrated metabolomics and transcriptomics analysis highlight key pathways involved in the somatic embryogenesis of Darjeeling tea.BMC genomics · 2024Article
- The miRNA-mRNA Regulatory Modules ofInternational journal of molecular sciences · 2023Article
- C-H Groups as Donors in Hydrogen Bonds: A Historical Overview and Occurrence in Proteins and Nucleic Acids.International journal of molecular sciences · 2023Review
- QTL mapping: insights into genomic regions governing component traits of yield under combined heat and drought stress in wheat.Frontiers in genetics · 2023Article
- Integrating biochemical and anatomical characterizations with transcriptome analysis to dissect superior stem strength of ZS11 (Frontiers in plant science · 2023Article
- The Role of the mGenes · 2022Review
- Comparative Transcriptomics and Metabolites Analysis of Two Closely RelatedFrontiers in plant science · 2022Article
- The dynamics of NGenome biology · 2021Article
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3 authors at 3 institutions in 2 countries.
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Abstract
S-adenosylmethionine synthases (MATs) are responsible for production of S-adenosylmethionine, the cofactor essential for various methylation reactions, production of polyamines and phytohormone ethylene, etc. Plants have two distinct MAT types (I and II). This work presents the structural analysis of MATs from Arabidopsis thaliana (AtMAT1 and AtMAT2, both type I) and Medicago truncatula (MtMAT3a, type II), which, unlike most MATs from other domains of life, are dimers where three-domain subunits are sandwiched flat with one another. Although MAT types are very similar, their subunits are differently oriented within the dimer. Structural snapshots along the enzymatic reaction reveal the exact conformation of precatalytic methionine in the active site and show a binding niche, characteristic only for plant MATs, that may serve as a lock of the gate loop. Nevertheless, plants, in contrary to mammals, lack the MAT regulatory subunit, and the regulation of plant MAT activity is still puzzling. Our structures open a possibility of an allosteric activity regulation of type I plant MATs by linear compounds, like polyamines, which would tighten the relationship between S-adenosylmethionine and polyamine biosynthesis.
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