Evidence map›Paper›PMID 32057825›Full record

ReviewExperimental gerontology2020

Impact of calorie restriction on energy metabolism in humans.

Jasper Most, Leanne Maree Redman

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379802 (Lifestyle Intervention With Physical Activity and Diet for Precision Health in Individuals With Overweight), which is not on this map. Cited by 96 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 6 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06379802 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Lifestyle Intervention With Physical Activity and Diet for Precision Health in Individuals With Overweight: a 6-month Pilot Randomized Controlled Trial (LI-PAD)

TypeinterventionalSponsorVastra Gotaland RegionRan2024 to 2027Enrolled120ConditionsOverweightArmsIndividualized physical activity and diet
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 6 syntheses or guidelines pooled it, 148 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Jasper MostPennington Biomedical Research Center, Baton Rouge 70808, LA, USA; Nutrition and Movement Sciences, Maastricht University Medical Center+, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands. Electronic address: jasper.most@pbrc.edu.
Leanne Maree RedmanPennington Biomedical Research Center, Baton Rouge 70808, LA, USA. Electronic address: leanne.redman@pbrc.edu.
Pennington Biomedical Research Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Calorie restriction (CR) is the most potent, non-pharmacological intervention to support metabolic health. The effects of calorie restriction exceed weight loss. Consistent throughout many studies, calorie restriction induces a reduction in energy expenditure that is larger than the loss of metabolic mass, i.e. fat-free mass and fat mass, can explain. Per prevailing theories of mammalian aging, this disproportionate reduction in metabolic rate, defined as metabolic adaptation, reduces oxidative damage and thereby delays age-associated declines in physiological function. The aim of this narrative review is to investigate the origins of CR-induced metabolic adaptation. From a physiological standpoint this likely relates to the composition of body weight loss, reductions in insulin secretion, thyroid and leptin concentrations, and increased mitochondrial energy efficiency. Behavioral factors including physical activity and eating behaviors likely also play a role, specifically to prevent weight regain. Future studies are required to understand the interindividual differences in the response to CR, e.g. by sex, physical activity, or mitochondrial capacity, and to assess the long-term implications of CR for weight regain.

Indexed as

Body CompositionCaloric RestrictionAnimalsBody Mass IndexEnergy MetabolismHumansWeight LossAdaptive thermogenesisCalorie restrictionEnergy efficiencyEnergy requirementsWeight lossWeight regain

Identifiers

PMID32057825
PMCPMC9036397
OpenAlexW3006405319

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.