Evidence map›Paper›PMID 32057766›Full record

ArticleThe Journal of allergy and clinical immunology2020

On the cause and consequences of IgE to galactose-α-1,3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on Understanding IgE-Mediated Mammalian Meat Allergy.

Thomas A E Platts-Mills, Scott P Commins, Tilo Biedermann, Marianne van Hage, Michael Levin, Lisa A Beck, Maria Diuk-Wasser, Uta Jappe, Danijela Apostolovic, Michael Minnicozzi and 2 more

Open access · greenAbstract readConsensus Development Conference, NIH
In one paragraph

Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 123 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Is Zebrafish a Good Model for the Alpha-Gal Syndrome?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Chronic Spontaneous Urticaria: Etiology and Pathogenesis.Immunology and allergy clinics of North America · 2024
    Review
  17. Article
  18. Review
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 4 countries.

Thomas A E Platts-MillsDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va. Electronic address: tap2z@virginia.edu.
Scott P ComminsDepartments of Medicine & Pediatrics, University of North Carolina, Chapel Hill, NC.
Tilo BiedermannDepartment of Dermatology and Allergy, Technical University of Munich and Unit Clinical Allergology (EKA), Helmholtz Zentrum München, Munich, Germany.
Marianne van HageDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Michael LevinDivision of Paediatric Allergy, University of Cape Town, Cape Town, South Africa.
Lisa A BeckDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY.
Maria Diuk-WasserDepartment of Ecology, Evolution, and Environmental Biology, Columbia University, New York, NY.
Uta JappeDivision of Clinical and Molecular Allergology, Research Center Borstel, Airway Research, Center North (ARCN), Member of the German Center for Lung Research, Borstel, Germany; Interdisciplinary Allergy Outpatient Clinic, Department of Pneumology, University of Lübeck, Lübeck, Germany.
Danijela ApostolovicDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Michael MinnicozziDivision of Allergy, Immunology and Transplantation, Allergy, Asthma and Airway Biology Branch, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Md.
Marshall PlautDivision of Allergy, Immunology and Transplantation, Allergy, Asthma and Airway Biology Branch, National Institute of Allergy and Infectious Diseases, NIH, Rockville, Md.
Jeffrey M WilsonDivision of Allergy & Clinical Immunology, University of Virginia, Charlottesville, Va.
Karolinska University Hospital · SENational Institute of Allergy and Infectious Diseases · USUniversity of Virginia · USColumbia University · USGerman Center for Lung Research · DEHelmholtz Zentrum München · DEUniversity of Cape Town · ZAUniversity of North Carolina at Chapel Hill · USUniversity of Rochester Medical Center · US

Funding

INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
IgE antibodies to the mammalian oligosaccharide galactose-alpha-1, 3-galactose (alpha-gal): immunology, epidemiology and relevance to allergic and inflammatory diseaseR37AI020565 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI THOMAS A. PLATTS-MILLS · 1992 to 2026
$8.4M
Understanding alpha-gal red meat allergyR01AI135049 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott Palmer Commins · 2018 to 2026
$5.1M
IgE to carbohydrates causes delayed anaphylaxisK08AI085190 · NIAID · UNIVERSITY OF VIRGINIA · PI COMMINS, SCOTT PALMER · 2010 to 2014
$651k
Delayed Anaphylaxis to Mammalian Meat caused by IgE Ab to alpha-galR56AI113095 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COMMINS, SCOTT PALMER · 2014 to 2014
$390k
NIAID NIH HHS K08 AI085190NIAID NIH HHS R01 AI135049NIAID NIH HHS R37 AI020565NIAID NIH HHS R56 AI113095
6 · The paper itself

Abstract

The mammalian meat allergy known as the "α-Gal syndrome" relates to IgE specific for galactose-α-1,3-galactose (α-Gal), an oligosaccharide that is present in cells and tissues of nonprimate mammals. The recognition of delayed reactions to food derived from mammals in patients with IgE to α-Gal and also the association with tick bites have been increasing worldwide. In 2018, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on this emerging tick-related disease. International experts from the fields of tick biology, allergy, immunology, infectious disease, and dermatology discussed the current state of our understanding of this emerging medical condition. The participants provided suggestions for specific research priorities and for the development of resources to advance our knowledge of the mechanisms, diagnosis, management, and prevention of this allergic disease. This publication is a summary of the workshop and the panel's recommendations are presented herein.

Indexed as

Allergensalpha-GalactosidaseAnimalsFood HypersensitivityImmunoglobulin EMeat ProteinsNational Institute of Allergy and Infectious Diseases (U.S.)Tick-Borne DiseasesTicksUnited StatesAllergensalpha-GalactosidaseGLA protein, humanImmunoglobulin EMeat ProteinsanaphylaxisglycolipidsIgEmammalian meat allergyoligosaccharide allergenticksα-Gal

Identifiers

PMID32057766
PMCPMC7301618
OpenAlexW3004971847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.