Evidence map›Paper›PMID 32057637›Full record

Observational studyNeuromuscular disorders : NMD2020

A cross-sectional study of hand function in inclusion body myositis: Implications for functional rating scale.

Ava Yun Lin, Maggie Clapp, Elizabeth Karanja, Kevin Dooley, Conrad C Weihl, Leo H Wang

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neuromuscular disorders : NMD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ava Yun LinDepartment of Neurology, University of Washington Medical Center, Box 356465, 1959 NE Pacific Street. Seattle, WA 98195-6465, United States; Department of Neurology, Stanford Neuroscience Health Center, 213 Quarry Road, M/C 5956, Palo Alto, CA 94305, United States. Electronic address: avaylin@stanford.edu.
Maggie ClappDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 South Euclid Ave, St. Louis, MO 63110, United States.
Elizabeth KaranjaDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 South Euclid Ave, St. Louis, MO 63110, United States.
Kevin DooleyCure IBM, Davis, CA, United States.
Conrad C WeihlDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 South Euclid Ave, St. Louis, MO 63110, United States.
Leo H WangDepartment of Neurology, University of Washington Medical Center, Box 356465, 1959 NE Pacific Street. Seattle, WA 98195-6465, United States. Electronic address: leowang@uw.edu.
Washington University in St. Louis · USUniversity of Washington Medical Center · US

Funding

VCP in myopathy and dementiaR01AG031867 · NIA · WASHINGTON UNIVERSITY · PI CONRAD C WEIHL · 2009 to 2026
$9.1M
Clinical and Translational Studies in Muscle DiseaseK24AR073317 · NIAMS · WASHINGTON UNIVERSITY · PI CONRAD C WEIHL · 2018 to 2026
$1.6M
NIAMS NIH HHS K24 AR073317NIA NIH HHS R01 AG031867
6 · The paper itself

Abstract

Inclusion body myositis (IBM) is a slowly progressive and heterogeneous disorder that is a challenge for measuring clinical trial efficacy. The current methods of measuring progression of the disease utilizes the Inclusion Body Myositis Functional Rating Scale, grip strength by dynamometer, and finger flexor strength. One of the hallmarks of the disease is selective deep finger flexor weakness. To date, no adequate data has been available to determine how well the Functional Rating Scale relates to this hallmark physical exam deficit. Our study is the first to investigate the degree of correlation between items pertaining to hand function in the Functional Rating Scale with measured grip and finger flexor strength in IBM patients. We have found a lower than expected correlation with finger flexor strength and even lower with grip strength. The current Functional Rating Scale will benefit from optimization to measure clinical progression more accurately.

Indexed as

Severity of Illness IndexAdultAgedAged, 80 and overCross-Sectional StudiesFemaleFingersHandHand StrengthHumansMaleMiddle AgedMyositis, Inclusion BodyFunctional rating scaleInclusion body myositis

Identifiers

PMID32057637
PMCPMC9724478
OpenAlexW2996692879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.