Evidence map›Paper›PMID 32057462›Full record

ArticleCurrent problems in cancer2020

Gut microbiota differences in Island Hispanic Puerto Ricans and mainland non-Hispanic whites during chemoradiation for rectal cancer: A pilot study.

Velda J González-Mercado, Jean Lim, Lawrence Berk, Mary Esele, Carmen S Rodríguez, Gerardo Colón-Otero

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current problems in cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Gut microbiota and fatigue in rectal cancer patients: a cross-sectional pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Velda J González-MercadoCollege of Nursing, University of South Florida, Tampa, Florida. Electronic address: veldag@usf.edu.
Jean LimCollege of Nursing, University of South Florida, Tampa, Florida.
Lawrence BerkRadiation Oncology, College of Medicine Radiology, University of South Florida, Tampa, Florida.
Mary EseleSchool of Nursing, South University, Tampa, Florida.
Carmen S RodríguezCollege of Nursing, University of South Florida, Tampa, Florida.
Gerardo Colón-OteroDivision of Hematology-Oncology, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Jacksonville, Florida.

Funding

Fatigue and the Gut Microbiome of Patients Receiving Chemoradiotherapy for Rectal CancerF32NR016618 · NINR · UNIVERSITY OF SOUTH FLORIDA · PI GONZALEZ-MERCADO, VELDA JANET · 2017 to 2019
$180k
NINR NIH HHS F32 NR016618
6 · The paper itself

Abstract

purposeTo investigate whether there are differences in diversity, taxonomic composition, and predicted functional pathways of the gut microbiome between Island Hispanic Puerto Ricans (HPR) and mainland non-Hispanic whites (NHW) measured before and at the end of chemo-radiation (CRT) for Rectal Cancer.

methodsFifty-six stool samples of newly diagnosed rectal cancer patients (25 HPR and 31 NHW) were amplicon-sequenced during chemo-radiotherapy. 16S rRNA gene data was analyzed using QIIME2, phyloseq, and LEfSe.

resultsWe observed similar within-sample alpha diversity for HPR and NHW participants during CRT. However, at the end of CRT, several taxa were present at significantly different abundances across both groups. Taxa enriched in the gut of HPR compared to NHW included Muribaculaceae, Prevotella 2 and 7, Gemella, Bacillales Family XI, Catenibacterium, Sutterella, Pasteurellales, and Pasteurellaceae genera, whereas over-represented taxa in NHW participants were Turicibacter and Eubacteriaceae. Significant differences in predicted HPR microbiota functions included pathways for synthesis of L-methionine and degradation of phenylethylamine and phenylacetate.

conclusionIn this pilot study, taxonomic analyses and functional predictions of the gut microbiomes suggest greater inflammatory potential in gut microbial functions among HPR rectal cancer patients undergoing CRT compared to that of NHW participants.

Indexed as

Gastrointestinal MicrobiomeChemoradiotherapyFemaleFollow-Up StudiesHispanic or LatinoHumansMaleMiddle AgedPilot ProjectsPrognosisPuerto RicoRectal NeoplasmsUnited StatesWhite PeopleChemo-radiationGut microbiota differencesIsland Hispanic Puerto RicansMainland non-Hispanic whitesRectal cancer

Identifiers

PMID32057462
PMCPMC7382976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.