ArticleeLife2020
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Gene signature discovery and systematic validation across diverse clinical cohorts for TB prognosis and response to treatment.PLoS computational biology · 2023Pooled it
- cGAS-STING signaling in the anterior cingulate cortex modulates electroacupuncture analgesia in a rat neuropathic pain model.The Korean journal of pain · 2026Article
- The cGAS-STING Pathway: A Double-Edged Regulator of Neuroinflammation and Myelin Regeneration.Molecular neurobiology · 2026Review
- DNA Sensing and Neuroinflammation: Mechanistic Insights into cGAS-STING Biology and Therapeutic Translation in Age-Related Neurodegenerative Diseases.Molecular neurobiology · 2026Review
- LINGO4 coordinates ILC3-intrinsic IL-22 production and microbiota-mediated ILC3 homeostasis.The Journal of experimental medicine · 2026Article
- BTNL2 Inhibits Pyroptosis in H37Ra-Infected Macrophages by Maintaining Mitochondrial Homeostasis.Microorganisms · 2026Article
- Tissue-specific transcriptional epistasis between Prkn and Lrrk2 during mycobacterial infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.Molecular neurodegeneration · 2026Article
- Role of LRRK2 in physiological activities, diseases, and therapy.Chinese medical journal · 2026Review
- Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma.Nature communications · 2026Article
- Host mitochondrial DNA in bacterial pathogenesis: Friend, Foe, or Both?Archives of microbiology · 2026Review
- LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.bioRxiv : the preprint server for biology · 2026Article
- LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes.Frontiers in cellular neuroscience · 2026Article
- cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives.Journal of neuroinflammation · 2025Review
- Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis.NPJ Parkinson's disease · 2025Article
- LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.The Biochemical journal · 2025Review
- The Multifaceted Role of LRRK2 in Parkinson's Disease.Brain sciences · 2025Review
- CMPK2 promotes microglial activation through the cGAS-STING pathway in the neuroinflammatory mechanism.Scientific reports · 2025Article
- (Dys)regulation of the Immune System in Parkinson's Disease: Methodologies, Techniques, and Key Findings from Human Studies.Aging and disease · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Chi G Weindel *Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, United States.
Samantha L Bell *Department of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, United States.ORCID 0000-0002-5453-3203
Krystal J VailDepartment of Veterinary Pathobiology, Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, United States.ORCID 0000-0002-1964-7985
Kelsi O WestDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, United States.
Kristin L PatrickDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, United States.ORCID 0000-0003-2442-4679
Robert O WatsonDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, United States.ORCID 0000-0003-4976-0759
Texas A&M Health Science Center · USTexas A&M University · US
Funding
Comparative Biomedical Research Training for VeterinariansT32OD011083 · OD · TEXAS A&M AGRILIFE RESEARCH · PI ALBERT MULENGA · 2012 to 2026
$4.8MPre-mRNA splicing regulation is critical for controlling macrophage activationR35GM133720 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kristin Leigh Patrick · 2019 to 2026
$3.3MTRIM proteins polarize DNA sensing outcomes during the innate immune response to Mycobacterium tuberculosisR01AI125512 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI WATSON, ROBERT OWEN · 2016 to 2019
$1.5MMHC Class II Bare Lymphocyte Syndrome factorsR21AI034000 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2003 to 2003
$342kMichael J. Fox Foundation for Parkinson's Research 12185Michael J. Fox Foundation for Parkinson's Research M1801235National Institute of Allergy and Infectious Diseases 1R01AI12551NIAID NIH HHS N01 AI040004NIAID NIH HHS R01 AI125512NIAID NIH HHS R21 AI034000NIGMS NIH HHS R35 GM133720NIH HHS 5T32OD011083-10NIH HHS T32 OD011083
Abstract
The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (
Indexed as
HomeostasisImmunity, InnateAnimalsHumansInterferon Type ILeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMice, KnockoutMitochondriaMutationMycobacterium tuberculosisParkinson DiseaseSequence Analysis, RNAInterferon Type ILeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanbacterial pathogenesiscGASDRP1humanimmunologyinfectious diseaseinflammationmetabolismmicrobiologymouseparkinson's diseasepurine biosynthesis
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.