Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models.

Chen Liang, Qiang Shao, Wei Zhang, Mei Yang, Qing Chang, Rong Chen, Jian-Fu Chen

Open access · hybridAbstract readPublished Erratum

In one paragraph

Article in Human molecular genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.1field-weighted citation impact, top 19% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.Nucleic acids research · 2025
Article
Cellular and physiological functions of C9ORF72 and implications for ALS/FTD.Journal of neurochemistry · 2021
Review

4 · The record

Corrections and comments

Erratum for
Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models.2019

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chen LiangCenter for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033, USA.

Qiang ShaoCenter for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033, USA.

Wei ZhangCenter for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033, USA.

Mei YangCenter for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033, USA.

Qing ChangCenter for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033, USA.

Rong ChenDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 100 N. Greene Street, Baltimore, MD 21205, USA.

Jian-Fu ChenCenter for Craniofacial Molecular Biology, University of Southern California (USC), Los Angeles, CA 90033, USA.

University of Southern California · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID32057072

DOI10.1093/hmg/ddaa012

PMCPMC7158374

OpenAlexW2980356173

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.