ArticleJournal of affective disorders2020
Minimally important differences and severity thresholds are estimated for the PROMIS depression scales from three randomized clinical trials.
Article in Journal of affective disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 88 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Care Management for the Effective Use of Opioids (CAMEO)
Stroke Self-Management: Effect on Function and Stroke Quality of Life
Who cites it
88 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The effectiveness of second-generation mindfulness interventions on anxiety and depression: A systematic review and meta-analysis.Clinical psychology review · 2026Pooled it
- Resistance training for fatigue in people with cancer.The Cochrane database of systematic reviews · 2024Pooled it
- Measurement properties and interpretability of the PROMIS item banks in stroke patients: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Pooled it
- Minimal important change (MIC): a conceptual clarification and systematic review of MIC estimates of PROMIS measures.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Clinical Trial: Effectiveness and Safety of a Novel Anal Insert Device for Treatment of Faecal Incontinence.Alimentary pharmacology & therapeutics · 2026Trial
- Randomized comparative effectiveness study of 1-session vs 8-session online behavioral treatment for chronic pain: protocol for the national PROGRESS study.Pain medicine (Malden, Mass.) · 2026Trial
- Prevalence and Predictors of Self-Reported Adverse Experiences in Digital Meditation Training: 2 Randomized Controlled Trials.JMIR mental health · 2026Trial
- Genotype-Guided Antidepressant Prescribing for Patients With Depression: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Online 1-session Empowered Relief in Marfan syndrome and related diseases: a single-arm feasibility and pilot efficacy study.Scientific reports · 2026Trial
- How often should I meditate? A randomized trial examining the role of meditation frequency when total amount of meditation is held constant.Journal of counseling psychology · 2024Trial
- Feasibility and acceptability of an integrated mind-body intervention for depression: whole-body hyperthermia (WBH) and cognitive behavioral therapy (CBT).International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2024Trial
- A Hybrid Effectiveness/Implementation Clinical Trial of Adherence to Long-Term Oxygen Therapy for Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2023Trial
- Prevalence, Severity, and Co-Occurrence of SPPADE Symptoms in 31,866 Patients With Cancer.Journal of pain and symptom management · 2023Trial
- An app-based just-in-time-adaptive self-management intervention for care partners: The CareQOL feasibility pilot study.Rehabilitation psychology · 2022Trial
- Web-Based Mindfulness-Based Interventions for Well-being: Randomized Comparative Effectiveness Trial.Journal of medical Internet research · 2022Trial
- Effectiveness of Internet-Based Cognitive Behavioral Therapy With Telephone Support for Noncardiac Chest Pain: Randomized Controlled Trial.Journal of medical Internet research · 2022Trial
- Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.Journal of the American Geriatrics Society · 2021Trial
- Caregiving Burden and Wellbeing From the Meta-LARC Cluster Randomized Trial of Advance Care Planning in Primary Care for Patients With Serious Illness.Journal of primary care & community healthTrial
- Article
- Empowered Relief vs Cognitive Behavioral Therapy for Patients With Systemic Lupus Erythematosus and Chronic Pain: Study Protocol for a National, Randomized, Noninferiority Trial.JMIR research protocols · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPatient Reported Outcomes Measurement Information Systems (PROMIS) scales are increasingly being used to measure symptoms in research and practice. The purpose of this study was to determine the minimally important difference (MID) and severity thresholds (cut-points) for the four fixed-length PROMIS depression scales.
methodsThe study sample was adult participants in three randomized clinical trials (N=651). MID was estimated using multiple distribution- and anchor-based approaches including assessing correspondence between Patient Health Questionnaire (PHQ-9) and PROMIS depression scores.
resultsThe best MID estimate was a PROMIS depression T-score of 3.5 points with most methods producing an MID in the 3 to 4 point range across all three samples. MID estimates were similar for all four PROMIS scales. A PHQ-9 1-point change equated to a PROMIS 1.25-point T-score change. PROMIS T-scores of 55, 60, 65, and 70 appeared to be reasonable thresholds for mild, moderate, moderately severe, and severe depression, respectively. LIMITATIONS: The study sample was predominantly male veterans with either chronic pain (2 trials) or previous stroke (1 trial). The severity of depression was mild to moderate.
conclusionA T-score of 3 to 4 points is a reasonable MID for PROMIS depression scales and can be used to assess treatment effects in both practice and research as well to calculate sample sizes for clinical trials. Severity cut-points can help interpret the meaning of scores and action thresholds for treatment decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.