Evidence map›Paper›PMID 32056840›Full record

ArticleRespiratory medicine2020

Pulmonary arterial capacitance predicts outcomes in patients with pulmonary hypertension independent of race/ethnicity, sex, and etiology.

Jacob J Mayfield, Alexander Papolos, Elena Vasti, Teresa De Marco, Geoffrey H Tison

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jacob J MayfieldDepartment of Medicine, University of California, San Francisco, USA.
Alexander PapolosDepartment of Cardiology, Medstar Washington Hospital Center, Washington, DC, USA.
Elena VastiDepartment of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Teresa De MarcoDepartment of Medicine, University of California, San Francisco, USA; Division of Cardiology, University of California, San Francisco, USA.
Geoffrey H TisonDepartment of Medicine, University of California, San Francisco, USA; Division of Cardiology, University of California, San Francisco, USA; Bakar Institute of Computational Health Sciences, University of California, San Francisco, USA; Cardiovascular Research Institute, University of California, San Francisco, USA. Electronic address: geoff.tison@ucsf.edu.
University of California, San Francisco · USMedStar Washington Hospital Center · USStanford University · US

Funding

Dynamic prediction of heart failure using real-time functional status and EHR data in the ambulatory settingK23HL135274 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TISON, GEOFFREY H · 2018 to 2022
$999k
NHLBI NIH HHS K23 HL135274
6 · The paper itself

Abstract

backgroundPulmonary arterial capacitance (PAC) is a strong hemodynamic predictor of outcomes in patients with pulmonary hypertension (PH). Its value across subgroups of race/ethnicity, sex, and PH etiologies is unclear. We hypothesized that the association of PAC with outcomes would not vary across World Health Organization (WHO) PH group, race/ethnicity, or sex.

methodsWe performed a retrospective study in patients with PH diagnosed and managed at the Pulmonary Hypertension Comprehensive Care Center of a tertiary care hospital (n = 270). Demographic, diagnostic, treatment, and outcome data were extracted from the electronic medical record. Cox proportional hazards models were used to model time from right heart catheterization to event in univariate and multivariable models. Our primary outcome was all-cause mortality and our secondary outcome was PH hospitalization.

resultsThe median age of the cohort was 56 years (±14.6), and 67% were female. In multivariable Cox models adjusted for significant covariates, decreased PAC remained independently and significantly associated with both all-cause mortality (p = 0.029) and hospitalization for PH (p = 0.010). No significant interactions were observed between PAC and race, sex, or WHO group. Hispanic patients exhibited a significant independent association with increased hospitalizations (p = 0.030), and there was a trend toward increased all-cause mortality in African Americans. WHO group 2 PH was associated with more frequent hospitalization (p = 0.004).

conclusionsDecreased PAC is significantly associated with mortality and hospitalization in PH patients independent of race, sex, and PH subgroups. Further investigation is required to characterize the effects and determinants of racial disparities in PH.

Indexed as

Vascular PatencyCohort StudiesFemaleHospitalizationHumansHypertension, PulmonaryMaleMiddle AgedPrognosisPulmonary ArteryRacial GroupsRetrospective StudiesSex FactorsHealth disparitiesPrognosisPulmonary arterial capacitancePulmonary hypertension

Identifiers

PMID32056840
PMCPMC7357872
OpenAlexW3004682719

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.