Evidence map›Paper›PMID 32056668›Full record

ArticleVirology2020

Whitefly HES1 binds to the intergenic region of Tomato yellow leaf curl China virus and promotes viral gene transcription.

Yu-Meng Wang, Ya-Zhou He, Xin-Tong Ye, Wen-Ze He, Shu-Sheng Liu, Xiao-Wei Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu-Meng WangMinistry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Ya-Zhou HeMinistry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Xin-Tong YeMinistry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Wen-Ze HeMinistry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Shu-Sheng LiuMinistry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China.
Xiao-Wei WangMinistry of Agriculture Key Laboratory of Molecular Biology of Crops Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, China. Electronic address: xwwang@zju.edu.cn.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intergenic region of begomovirus genome is vital to virus replication and viral gene transcription in plants. Previous studies have reported that Tomato yellow leaf curl China virus (TYLCCNV), a begomovirus, is able to accumulate and transcribe in its whitefly vector. However, the viral and host components that participate in begomovirus transcription in whiteflies are hitherto unknown. Using a yeast one-hybrid system, we identified >50 whitefly proteins that interacted with TYLCCNV intergenic region. Dual luciferase analysis revealed that one of the identified proteins, the hairy and enhancer of split homolog-1 (HES1), specifically bound to CACGTG motif in TYLCCNV intergenic region. Silencing HES1 decreased viral transcription, accumulation and transmission. These results demonstrate that the interactions between whitefly proteins and the intergenic region of TYLCCNV may contribute to viral transcription in the whitefly vector. Our findings offer valuable clues for the research and development of novel strategies to interfere with begomovirus transmission.

Indexed as

AnimalsBegomovirusDNA, IntergenicGene Knockdown TechniquesGenome, ViralHemipteraHost Microbial InteractionsInsect ProteinsInsect VectorsNicotianaPlant DiseasesProtein BindingSolanum lycopersicumTranscription Factor HES-1Transcription, GeneticTwo-Hybrid System TechniquesDNA, IntergenicInsect ProteinsTranscription Factor HES-1Bemisia tabaciHES1Intergenic regionTomato yellow leaf curl China virusViral gene transcription

Identifiers

PMID32056668
PMCPMC7031692
OpenAlexW3000955054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.