Evidence map›Paper›PMID 32056319›Full record

ArticleMycoses2020

First azole-resistant Aspergillus fumigatus isolates with the environmental TR

Fatemeh Ahangarkani, Ynze Puts, Mojtaba Nabili, Sadegh Khodavaisy, Maryam Moazeni, Zahra Salehi, Melika Laal Kargar, Hamid Badali, Jacques F Meis

Open access · hybridAbstract read
In one paragraph

Article in Mycoses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Global epidemiology of azole resistance inJAC-antimicrobial resistance · 2026
    Review
  2. Article
  3. Article
  4. An environmental isolate ofFrontiers in microbiology · 2024
    Article
  5. First Report of Azole-ResistantJournal of fungi (Basel, Switzerland) · 2023
    Article
  6. Clinical epidemiology of pulmonary aspergillosis in hospitalized patients and contribution of Cyp51A, Yap1, and Cdr1B mutations to voriconazole resistance in etiologic Aspergillus species.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  7. Exposure ofPathogens (Basel, Switzerland) · 2023
    Article
  8. Article
  9. Caspian Sea Mycosands: The Variety and Abundance of Medically Important Fungi in Beach Sand and Water.International journal of environmental research and public health · 2022
    Article
  10. Citizen Science Surveillance of Triazole-ResistantApplied and environmental microbiology · 2022
    Article
  11. Review
  12. Article
  13. Studies in mycology · 2021
    Review
  14. Review
  15. Article
  16. Molecular Epidemiology ofJournal of fungi (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Clonal Expansion of Environmental Triazole ResistantJournal of fungi (Basel, Switzerland) · 2020
    Article
  19. Article
  20. The Multi-Fungicide Resistance Status ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Fatemeh AhangarkaniStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.ORCID https://orcid.org/0000-0002-3629-7446
Ynze PutsDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Mojtaba NabiliDepartment of Medical Sciences, Sari Branch, Islamic Azad University, Sari, Iran.ORCID https://orcid.org/0000-0002-1461-4164
Sadegh KhodavaisyDepartment of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0001-8039-4991
Maryam MoazeniDepartment of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID https://orcid.org/0000-0001-6581-2139
Zahra SalehiDepartment of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Melika Laal KargarDepartment of Mycology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Hamid BadaliDepartment of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.ORCID https://orcid.org/0000-0002-6010-8414
Jacques F MeisDepartment of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0003-3253-6080
Canisius-Wilhelmina Ziekenhuis · NLTarbiat Modares University · IRIslamic Azad University Sari Branch · IRMazandaran University of Medical Sciences · IRRadboud University Nijmegen · NLTehran University of Medical Sciences · IRThe University of Texas Health Science Center at San Antonio · US

Funding

Mazandaran University of Medical Sciences 1352National Institutes for Medical Research Development (NIMAD) 982677
6 · The paper itself

Abstract

backgroundAzole resistance in Aspergillus fumigatus is an emerging problem and reported from all continents. As triazole antifungals are the mainstay of therapy in the management of invasive aspergillosis, azole-resistant A fumigatus has become a major medical concern and with complicated clinical management.

objectiveScreening of environmental presence of azole-resistant A fumigatus in Iran.

methodsCompost from Northern Iran, collected between 2017 and 2018, was screened for the presence of azole-resistant A fumigatus with azole-containing agar. Phenotypic MICs were obtained from selected, molecularly confirmed isolates. cyp51A gene sequencing and genotyping of azole-resistant isolates were done.

resultsAmong 300 compost samples, three A fumigatus isolates had high voriconazole MICs (≥16 mg/L) and harboured the TR

conclusionThis is the first report of A fumigatus with TR

Indexed as

Soil MicrobiologyAntifungal AgentsAspergillus fumigatusAzolesCompostingCytochrome P-450 Enzyme SystemDrug Resistance, FungalFungal ProteinsGenotypeIranMicrobial Sensitivity TestsMicrosatellite RepeatsMutationSequence Analysis, DNAAntifungal AgentsAzolescytochrome P-450 CYP51A, AspergillusCytochrome P-450 Enzyme SystemFungal ProteinsAspergillus fumigatusazole resistancecompostTR34/L98HTR46/Y121F/T289A

Identifiers

PMID32056319
PMCPMC7217147
OpenAlexW3006495955

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.