ArticleIndian journal of pediatrics2020
Is Lower Vitamin D Level Associated with Increased Risk of Neonatal Sepsis? A Prospective Cohort Study.
Article in Indian journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Vitamin D status was associated with sepsis in critically ill children: A PRISMA compliant systematic review and meta-analysis.Medicine · 2021Pooled it
- Vitamin D and Neonatal Sepsis: Current Evidence, Biological Mechanisms, and Future Directions-A Scoping Review.Nutrients · 2026Article
- Article
- Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study.Italian journal of pediatrics · 2024Article
- Oxygen therapy for sepsis and prevention of complications.Acute and critical care · 2022Article
- Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China.Frontiers in pediatrics · 2022Article
- Effects of vitamin D on neonatal sepsis: A systematic review and meta-analysis.Food science & nutrition · 2021Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of maternal/ neonatal vitamin D levels on culture positive neonatal sepsis.
methodsThis prospective cohort study was conducted in the NICU of a tertiary care teaching hospital in Odisha, Eastern India from January 2015 through December 2016. Forty (40) neonates with culture positive sepsis were included in the study group. Forty (40) healthy neonates admitted for evaluation of neonatal jaundice who are similar in gender, gestational age, postnatal age and without any clinical signs of sepsis were recruited as control group after informed consent. Vitamin D level (25 OH D) was assessed in the neonates and their mothers in both the groups.
resultsNeonatal 25 OH vitamin D level in the study group (12.71 ± 2.82 ng/ml) was significantly lower than in the control group (25.46 ± 7.02 ng/ml). The Odds ratio was 273 (95% CI 30.39-2451.6) for culture positive sepsis in neonates with vitamin D deficiency/insufficiency. Mothers of septic neonates had significantly lower 25 OH vitamin D level (20.92 ± 3.92 ng/ml) than the mothers of healthy neonates in control group (27.31 ± 6.83 ng/ml). The Odds ratio was 4.71 (95% CI 1.69-13.1) for culture positive sepsis in babies born to mothers with vitamin D deficiency/insufficiency.
conclusionsNeonates with vitamin D deficiency/insufficiency are at higher risk for developing sepsis than those with sufficient vitamin D levels. Lower vitamin D levels in mothers is also associated with increased risk of sepsis in the neonates.
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