Evidence map›Paper›PMID 32056145›Full record

ArticleJournal of neuro-oncology2020

A genome-wide association study on medulloblastoma.

Anna M Dahlin, Carl Wibom, Ulrika Andersson, Jonas Bybjerg-Grauholm, Isabelle Deltour, David M Hougaard, Michael E Scheurer, Ching C Lau, Roberta McKean-Cowdin, Rebekah J Kennedy and 18 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Associations betweenPediatric investigation · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 10 institutions in 7 countries.

Anna M DahlinDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.ORCID http://orcid.org/0000-0002-6754-2571
Carl WibomDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Ulrika AnderssonDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Jonas Bybjerg-GrauholmDanish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Isabelle DeltourSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
David M HougaardDanish Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Michael E ScheurerDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Ching C LauDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Roberta McKean-CowdinDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rebekah J KennedyChildren's Center for Cancer and Blood Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Long T HungDepartment of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Janis YeeDepartment of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Ashley S MargolDepartment of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Jessica Barrington-TrimisDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
W James GaudermanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Maria FeychtingUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Joachim SchüzSection of Environment and Radiation, International Agency for Research on Cancer, Lyon, France.
Martin RöösliDepartment of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Kristina KjaerheimThe Cancer Registry of Norway, Oslo, Norway.
Cefalo Study Group
Danuta Januszkiewicz-LewandowskaInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Marta FichnaDepartment of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.
Jerzy NowakInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Susan Searles NielsenPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Shahab AsgharzadehDepartment of Pediatrics, Section of Hematology-Oncology, Children's Hospital Los Angeles and The Saban Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
Lisa MirabelloDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ulf HjalmarsDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
Beatrice MelinDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. beatrice.melin@umu.se.
University of Southern California · USUmeå University · SEStatens Serum Institut · DKPoznan University of Medical Sciences · PLSwiss Tropical and Public Health Institute · CHBaylor College of Medicine · USFred Hutch Cancer Center · USInstitute of Human Genetics · PLKarolinska Institutet · SENational Institutes of Health · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
Gene-Environment Factors in Childhood Brain TumorsR01CA116724 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MUELLER, BETH A · 2006 to 2008
$664k
Exploring Gene-Environment Factors in Child Brain TumorsR03CA106011 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MUELLER, BETH A · 2003 to 2004
$173k
NCI NIH HHS P01 CA196569NCI NIH HHS R01 CA116724NCI NIH HHS R03 CA106011NIEHS NIH HHS P30 ES007033NIH HHS P30ES007033NIH HHS R01CA116724NIH HHS R03CA106011World Health Organization 001
6 · The paper itself

Abstract

introductionMedulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS) including 244 medulloblastoma cases and 247 control subjects from Sweden and Denmark.

methodsGenotyping was performed using Illumina BeadChips, and untyped variants were imputed using IMPUTE2.

resultsFifty-nine variants in 11 loci were associated with increased medulloblastoma risk (p < 1 × 10

conclusionThe results of this study, including a novel potential medulloblastoma risk loci at 18p11.23, are suggestive but need further validation in independent cohorts.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyPolymorphism, Single NucleotideBiomarkers, TumorCase-Control StudiesCerebellar NeoplasmsCohort StudiesGenotypeHumansMedulloblastomaPrognosisBiomarkers, TumorAdolescents and young adults (AYA)CNS cancersEpidemiologyGenetics of risk, outcome, and preventionPediatric cancers

Identifiers

PMID32056145
PMCPMC7136185
OpenAlexW3006165356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.