Evidence map›Paper›PMID 32056073›Full record

ArticleJournal of clinical immunology2020

Lymphocyte Subgroups and KREC Numbers in Common Variable Immunodeficiency: A Single Center Study.

Ismail Yaz, Begum Ozbek, Yuk Yin Ng, Pinar Gur Cetinkaya, Sevil Oskay Halacli, Cagman Tan, Merve Kasikci, Can Kosukcu, Ilhan Tezcan, Deniz Cagdas

Abstract read
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In one paragraph

Article in Journal of clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ismail YazInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey.ORCID 0000-0001-5278-7456
Begum OzbekInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey.
Yuk Yin NgDepartment of Genetics and Bioengineering, Faculty of Engineering and Natural Sciences, İstanbul Bilgi University, İstanbul, Turkey.
Pinar Gur CetinkayaInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey.
Sevil Oskay HalacliInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey.
Cagman TanInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey.
Merve KasikciDepartment of Biostatistics, Institute of Health Sciences, Hacettepe University, Ankara, Turkey.
Can KosukcuDepartment of Bioinformatics, Institute of Health Sciences, Hacettepe University, Ankara, Turkey.
Ilhan TezcanInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey.
Deniz CagdasInstitute of Child Health, Section of Pediatric Immunology, Hacettepe University Institute of Health Sciences, Ihsan Dogramaci Children's Hospital, Altındağ, 06100, Ankara, Turkey. deniz.ayvaz@hacettepe.edu.tr.
Hacettepe University Hospital · TRHacettepe University · TRIstanbul Bilgi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Common variable immunodeficiency (CVID) results in defective B cell differentiation and impaired antibody production and is the most common symptomatic primary immunodeficiency. Our aim was to evaluate the correlation among B cell subgroups, κ-deleting recombination excision circle (KREC) copy numbers, and clinical and immunological data of the patients with CVID, and evaluate the patients according to classifications currently available to define the role of KREC copy numbers in the diagnosis of CVID. KREC analysis was performed using a quantitative real-time polymerase chain reaction assay, and B cell subgroups were measured by flow cytometry. The median age of the patients (n = 30) was 25 (6-69) years. Parental consanguinity ratio was 33%. The median age at diagnosis was 15 (4-59), and follow-up period was 6 (1-37) years. CD19

Indexed as

AdolescentAdultAgedAntigens, CDAntigens, CD19B-LymphocytesChildChild, PreschoolCommon Variable ImmunodeficiencyDNA, RecombinantFemaleFlow CytometryHumansImmunoglobulin kappa-ChainsLymphocyte SubsetsLymphopeniaAntigens, CDAntigens, CD19DNA, RecombinantImmunoglobulin kappa-ChainsB cellsCVIDFlow cytometryKRECsqRT-PCR

Identifiers

PMID32056073
OpenAlexW3005535555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.