SynthesisActa neurochirurgica2021
Treating Morton's neuroma by injection, neurolysis, or neurectomy: a systematic review and meta-analysis of pain and satisfaction outcomes.
Synthesis in Acta neurochirurgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Treatments for Morton's neuroma.The Cochrane database of systematic reviews · 2024Pooled it
- Effect of surgical approach on the treatment of Morton's neuroma: a systematic review and meta-analysis.Journal of foot and ankle research · 2023Pooled it
- Infiltrative Therapy of Morton's Neuroma.Acta bio-medica : Atenei Parmensis · 2022Pooled it
- Long-term comparison between blind and ultrasound-guided corticoid injections in Morton neuroma.European radiology · 2022Trial
- Rethinking Morton's neuroma: a sonographic study of bilateral prevalence and symmetry.Journal of orthopaedic surgery and research · 2026Article
- Radiofrequency neurolysis versus surgical neurectomy for Morton's Neuroma.International orthopaedics · 2026Observational
- The role of radiofrequency therapy in the treatment of Morton's neuroma: A case report.International journal of surgery case reports · 2025Article
- Morton's Neuroma or Intermetatarsal Bursitis-A Prospective Diagnostic Study of Intermetatarsal Pain.Diagnostics (Basel, Switzerland) · 2025Article
- Single metatarsal percutaneous distal metatarsal osteotomy (DMMO) for 3Archives of orthopaedic and trauma surgery · 2025Article
- Update/Refinement of Targeted Muscle Reinnervation Indication: A Scoping Review of Applications for Non-Amputees.Journal of clinical medicine · 2024Article
- Agents Used for Nerve Blocks and Neurolysis.Seminars in interventional radiology · 2022Review
- State of the Art and Advances in Peripheral Nerve Surgery.Advances and technical standards in neurosurgery · 2022Review
- Anatomic basis for a new ultrasound-guided, mini-invasive technique for release of the deep transverse metatarsal ligament.Clinical anatomy (New York, N.Y.) · 2021Article
- Ultrasound-guided treatment of Morton's neuroma.Journal of ultrasonography · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividual evidence suggests that multiple modalities can be used to treat entrapment pathology by Morton's neuroma, including injection, neurolysis, and neurectomy. However, their impacts on patient pain and satisfaction have yet to be fully defined or elucidated. Correspondingly, our aim was to pool systematically identified metadata and substantiate the impact of these different modalities in treating Morton's neuroma with respect to these outcomes.
methodsSearches of 7 electronic databases from inception to October 2019 were conducted following PRISMA guidelines. Articles were screened against pre-specified criteria. The incidences of outcomes were extracted and pooled by random-effects meta-analysis of proportions.
resultsA total of 35 articles satisfied all criteria, reporting a total of 2998 patients with Morton's neuroma managed by one of the three modalities. Incidence of complete pain relief after injection (43%; 95% CI, 23-64%) was significantly lower than neurolysis (68%; 95% CI, 51-84%) and neurectomy (74%; 95% CI, 66-82%) (P = 0.02). Incidence of complete satisfaction after injection (35%; 95% CI, 21-50%) was significantly lower than neurolysis (63%; 95% CI, 50-74%) and neurectomy (57%; 95% CI, 47-67%) (P < 0.01). The need to proceed to further surgery was significantly greater following injection (15%; 95% CI, 9-23%) versus neurolysis (2%; 95% CI, 0-4%) or neurectomy (5%; 95% CI, 3-7%) (P < 0.01). Incidence of procedural complications did not differ between modalities (P = 0.30).
conclusionsAlthough all interventions demonstrated favorable procedural complication incidences, surgical interventions by either neurolysis or neurectomy appear to trend towards greater incidences of complete pain relief and complete patient satisfaction outcomes compared to injection treatment. The optimal decision-making algorithm for treatment for Morton's neuroma should incorporate these findings to better form and meet the expectations of patients.
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Registered trials
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