ArticleBrain structure & function2020
A positive influence of basal ganglia iron concentration on implicit sequence learning.
Article in Brain structure & function, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Excess iron in deep gray matter is associated with cognitive and functional decline: The mediating role of white matter myelin.NeuroImage · 2026Article
- Subcortical gray matter atrophy and iron deposition in patients with vascular dementia: a multimodal MRI study.Frontiers in neuroscience · 2026Article
- Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging.Neurobiology of aging · 2025Article
- Review
- Age group differences in learning-related activity reflect task stage, not learning stage.Behavioural brain research · 2022Article
- Implicit associative learning relates to basal ganglia gray matter microstructure in young and older adults.Behavioural brain research · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Iron homeostasis is important for maintaining normal physiological brain functioning. In two independent samples, we investigate the link between iron concentration in the basal ganglia (BG) and implicit sequence learning (ISL). In Study 1, we used quantitative susceptibility mapping and task-related fMRI to examine associations among regional iron concentration measurements, brain activation, and ISL in younger and older adults. In Study 2, we examined the link between brain iron and ISL using a metric derived from fMRI in an age-homogenous sample of older adults. Three main findings were obtained. First, BG iron concentration was positively related to ISL in both studies. Second, ISL was robust for both younger and older adults, and performance-related activation was found in fronto-striatal regions across both age groups. Third, BG iron was positively linked to task-related BOLD signal in fronto-striatal regions. This is the first study investigating the relationship among brain iron accumulation, functional brain activation, and ISL, and the results suggest that higher brain iron concentration may be linked to better neurocognitive functioning in this particular task.
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Registered trials
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