ArticleAnalytical and bioanalytical chemistry2020
Current and future requirements to industrial analytical infrastructure-part 2: smart sensors.
Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Artificial intelligence-driven digital twins in Pharma 4.0: transforming smart manufacturing, predictive quality assurance, and personalized drug delivery.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Review
- Becoming fully circular facilitated by PAT.Analytical and bioanalytical chemistry · 2025Article
- A process analyzer assembly for real-time automated near-infrared, Raman, and proton nuclear magnetic resonance spectroscopic monitoring enhanced by heterocovariance spectroscopy and chemometry applied to a Schiff base formation.Analytical and bioanalytical chemistry · 2025Article
- Iterative Regression of Corrective Baselines (IRCB): A New Model for Quantitative Spectroscopy.Journal of chemical information and modeling · 2024Article
- Metrological traceability in process analytical technologies and point-of-need technologies for food safety and quality control: not a straightforward issue.Analytical and bioanalytical chemistry · 2023Review
- Adoption of knowledge-graph best development practices for scalable and optimized manufacturing processes.MethodsX · 2023Article
- Autonomous Multi-Step and Multi-Objective Optimization Facilitated by Real-Time Process Analytics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- A Comprehensive IT Infrastructure for an Enzymatic Product Development in a Digitalized Biotechnological Laboratory.Advances in biochemical engineering/biotechnology · 2022Article
- CDMOs Play a Critical Role in the Biopharmaceutical Ecosystem.Frontiers in bioengineering and biotechnology · 2022Review
- SmartSpectrometer-Embedded Optical Spectroscopy for Applications in Agriculture and Industry.Sensors (Basel, Switzerland) · 2021Article
- Carbon Nanomaterials: Synthesis, Functionalization and Sensing Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow*.Angewandte Chemie (International ed. in English) · 2021Article
- Predictive Maintenance and Intelligent Sensors in Smart Factory: Review.Sensors (Basel, Switzerland) · 2021Review
- Towards smart biomanufacturing: a perspective on recent developments in industrial measurement and monitoring technologies for bio-based production processes.Journal of industrial microbiology & biotechnology · 2020Article
- The Sample, the Spectra and the Maths-The Critical Pillars in the Development of Robust and Sound Applications of Vibrational Spectroscopy.Molecules (Basel, Switzerland) · 2020Review
- Critical assessment of relevant methods in the field of biosensors with direct optical detection based on fibers and waveguides using plasmonic, resonance, and interference effects.Analytical and bioanalytical chemistry · 2020Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Complex processes meet and need Industry 4.0 capabilities. Shorter product cycles, flexible production needs, and direct assessment of product quality attributes and raw material attributes call for an increased need of new process analytical technologies (PAT) concepts. While individual PAT tools may be available since decades, we need holistic concepts to fulfill above industrial needs. In this series of two contributions, we want to present a combined view on the future of PAT (process analytical technology), which is projected in smart labs (Part 1) and smart sensors (Part 2). Part 2 of this feature article series describes the future functionality as well as the ingredients of a smart sensor aiming to eventually fuel full PAT functionality. The smart sensor consists of (i) chemical and process information in the physical twin by smart field devices, by measuring multiple components, and is fully connected in the IIoT 4.0 environment. In addition, (ii) it includes process intelligence in the digital twin, as to being able to generate knowledge from multi-sensor and multi-dimensional data. The cyber-physical system (CPS) combines both elements mentioned above and allows the smart sensor to be self-calibrating and self-optimizing. It maintains its operation autonomously. Furthermore, it allows-as central PAT enabler-a flexible but also target-oriented predictive control strategy and efficient process development and can compensate variations of the process and raw material attributes. Future cyber-physical production systems-like smart sensors-consist of the fusion of two main pillars, the physical and the digital twins. We discuss the individual elements of both pillars, such as connectivity, and chemical analytics on the one hand as well as hybrid models and knowledge workflows on the other. Finally, we discuss its integration needs in a CPS in order to allow its versatile deployment in efficient process development and advanced optimum predictive process control.
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