Evidence map›Paper›PMID 32055909›Full record

ArticleAnalytical and bioanalytical chemistry2020

Current and future requirements to industrial analytical infrastructure-part 2: smart sensors.

Tobias Eifert, Kristina Eisen, Michael Maiwald, Christoph Herwig

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Becoming fully circular facilitated by PAT.Analytical and bioanalytical chemistry · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. CDMOs Play a Critical Role in the Biopharmaceutical Ecosystem.Frontiers in bioengineering and biotechnology · 2022
    Review
  10. Article
  11. Review
  12. Advanced Real-Time Process Analytics for Multistep Synthesis in Continuous Flow*.Angewandte Chemie (International ed. in English) · 2021
    Article
  13. Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tobias EifertArbeitskreis Prozessanalytik, Gesellschaft Deutscher Chemiker, 60486, Frankfurt am Main, Germany.
Kristina EisenArbeitskreis Prozessanalytik, Gesellschaft Deutscher Chemiker, 60486, Frankfurt am Main, Germany.
Michael MaiwaldArbeitskreis Prozessanalytik, Gesellschaft Deutscher Chemiker, 60486, Frankfurt am Main, Germany.
Christoph HerwigArbeitskreis Prozessanalytik, Gesellschaft Deutscher Chemiker, 60486, Frankfurt am Main, Germany. christoph.herwig@tuwien.ac.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex processes meet and need Industry 4.0 capabilities. Shorter product cycles, flexible production needs, and direct assessment of product quality attributes and raw material attributes call for an increased need of new process analytical technologies (PAT) concepts. While individual PAT tools may be available since decades, we need holistic concepts to fulfill above industrial needs. In this series of two contributions, we want to present a combined view on the future of PAT (process analytical technology), which is projected in smart labs (Part 1) and smart sensors (Part 2). Part 2 of this feature article series describes the future functionality as well as the ingredients of a smart sensor aiming to eventually fuel full PAT functionality. The smart sensor consists of (i) chemical and process information in the physical twin by smart field devices, by measuring multiple components, and is fully connected in the IIoT 4.0 environment. In addition, (ii) it includes process intelligence in the digital twin, as to being able to generate knowledge from multi-sensor and multi-dimensional data. The cyber-physical system (CPS) combines both elements mentioned above and allows the smart sensor to be self-calibrating and self-optimizing. It maintains its operation autonomously. Furthermore, it allows-as central PAT enabler-a flexible but also target-oriented predictive control strategy and efficient process development and can compensate variations of the process and raw material attributes. Future cyber-physical production systems-like smart sensors-consist of the fusion of two main pillars, the physical and the digital twins. We discuss the individual elements of both pillars, such as connectivity, and chemical analytics on the one hand as well as hybrid models and knowledge workflows on the other. Finally, we discuss its integration needs in a CPS in order to allow its versatile deployment in efficient process development and advanced optimum predictive process control.

Indexed as

Cyber-physical systemDigital twinsIndustry 4.0Physical twinProcess analytical technologyProcess intelligenceSmart sensors

Identifiers

PMID32055909
PMCPMC7072042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.