ArticleCerebral cortex (New York, N.Y. : 1991)2020
A Cortico-Collicular Amplification Mechanism for Gap Detection.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Multiparametric Classification of Pure-tone Responses Distinguishes Neurons in Inferior Colliculus Subdivisions.bioRxiv : the preprint server for biology · 2026Article
- Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- A new function of offset response in the primate auditory cortex: marker of temporal integration.Communications biology · 2024Article
- Developmental trajectory and sex differences in auditory processing in a PTEN-deletion model of autism spectrum disorders.Neurobiology of disease · 2024Article
- Differential cholinergic innervation of lemniscal versus non-lemniscal regions of the inferior colliculus.Journal of chemical neuroanatomy · 2024Article
- Assessing the Cntnap2 knockout rat prepulse inhibition deficit through prepulse scaling of the baseline startle response curve.Translational psychiatry · 2023Article
- Listening loops and the adapting auditory brain.Frontiers in neuroscience · 2023Article
- Binaural advantages in sound temporal information processing by neurons in the rat inferior colliculus.Frontiers in neuroscience · 2023Article
- Diverse functions of the auditory cortico-collicular pathway.Hearing research · 2022Review
- Offset Responses in the Auditory Cortex Show Unique History Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- A genetically identified population of layer 4 neurons in auditory cortex that contributes to pre-pulse inhibition of the acoustic startle response.Frontiers in neural circuits · 2022Article
- Amyloid Pathology in the Central Auditory Pathway of 5XFAD Mice Appears First in Auditory Cortex.Journal of Alzheimer's disease : JAD · 2022Article
- 5XFAD mice show early-onset gap encoding deficits in the auditory cortex.Neurobiology of aging · 2020Article
- A Layer 3→5 Circuit in Auditory Cortex That Contributes to Pre-pulse Inhibition of the Acoustic Startle Response.Frontiers in neural circuits · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Auditory cortex (AC) is necessary for the detection of brief gaps in ongoing sounds, but not for the detection of longer gaps or other stimuli such as tones or noise. It remains unclear why this is so, and what is special about brief gaps in particular. Here, we used both optogenetic suppression and conventional lesions to show that the cortical dependence of brief gap detection hinges specifically on gap termination. We then identified a cortico-collicular gap detection circuit that amplifies cortical gap termination responses before projecting to inferior colliculus (IC) to impact behavior. We found that gaps evoked off-responses and on-responses in cortical neurons, which temporally overlapped for brief gaps, but not long gaps. This overlap specifically enhanced cortical responses to brief gaps, whereas IC neurons preferred longer gaps. Optogenetic suppression of AC reduced collicular responses specifically to brief gaps, indicating that under normal conditions, the enhanced cortical representation of brief gaps amplifies collicular gap responses. Together these mechanisms explain how and why AC contributes to the behavioral detection of brief gaps, which are critical cues for speech perception, perceptual grouping, and auditory scene analysis.
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