Evidence map›Paper›PMID 32055824›Full record

ArticleThe Journal of nutrition2020

Examination of Carbohydrate Products in Feces Reveals Potential Biomarkers Distinguishing Exclusive and Nonexclusive Breastfeeding Practices in Infants.

Christopher L Ranque, Carol Stroble, Matthew J Amicucci, Diane Tu, Aly Diana, Sofa Rahmannia, Aghnia Husnayiani Suryanto, Rosalind S Gibson, Ying Sheng, Jennyfer Tena and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Christopher L RanqueDepartment of Chemistry, University of California, Davis, CA, USA.
Carol StrobleDepartment of Chemistry, University of California, Davis, CA, USA.
Matthew J AmicucciDepartment of Chemistry, University of California, Davis, CA, USA.
Diane TuDepartment of Chemistry, University of California, Davis, CA, USA.
Aly DianaDepartment of Human Nutrition, University of Otago, Dunedin, New Zealand.
Sofa RahmanniaNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Aghnia Husnayiani SuryantoNutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Rosalind S GibsonDepartment of Human Nutrition, University of Otago, Dunedin, New Zealand.
Ying ShengDepartment of Chemistry, University of California, Davis, CA, USA.
Jennyfer TenaDepartment of Chemistry, University of California, Davis, CA, USA.
Lisa A HoughtonDepartment of Human Nutrition, University of Otago, Dunedin, New Zealand.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA, USA.
University of California, Davis · USPadjadjaran University · IDUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe stable isotope deuterium dose-to-mother (DTM) technique to estimate nonbreast milk water intake demonstrates that maternal self-report methods of infant feeding overestimate the true prevalence of exclusively breastfeeding practices.

objectiveWe aimed to determine potential monosaccharide and oligosaccharide markers that distinguish between exclusively breastfed (EBF) versus nonexclusively breastfed (non-EBF) infants utilizing LC-MS-based methods.

methodsData for the analysis were collected as part of a larger, longitudinal study of 192 breastfed Indonesian infants aged 2 mo and followed up at 5 mo. Feces samples were collected from infants aged 2 mo (n = 188) and 5 mo (n = 184). EBF and non-EBF strata at each time point were determined via the DTM technique. Feces samples were analyzed to determine monosaccharide content using ultra-high-performance LC-triple quadrupole MS (UHPLC-QqQ MS). Relative abundances of fecal oligosaccharides were determined using nano-LC-Chip-quadrupole time-of-flight MS (nano-LC-Chip-Q-ToF MS).

resultsAt age 2 mo, monosaccharide analysis showed the abundance of fructose and mannose were significantly higher (+377% and +388%, respectively) in non-EBF compared with EBF infants (P <0.0001). Fructose and mannose also showed good discrimination with areas under the curve (AUC) of 0.86 and 0.82, respectively. Oligosaccharide analysis showed that a 6-hexose (Hex6) isomer had good discrimination (AUC = 0.80) between EBF and non-EBF groups at 5 mo.

conclusionCarbohydrate products, particularly fecal mono- and oligosaccharides, differed between EBF and non-EBF infants aged under 6 mo and can be used as potential biomarkers to distinguish EBF versus non-EBF feeding practices.

Indexed as

Breast FeedingCarbohydrate MetabolismBiomarkersCarbohydratesFecesFemaleHumansInfantInfant Nutritional Physiological PhenomenaBiomarkersCarbohydratesbreast milkfecesLC-MSmonosaccharideoligosaccharide

Identifiers

PMID32055824
PMCPMC7198307
OpenAlexW3005725964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.