ArticleOpen forum infectious diseases2020
Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making.
Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Situation and questions regarding the practice of blood cultures in paediatric patients: an opinion paper.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Impact of switching from manual to automated aerobic blood culture on bacteremia diagnosis in Lao PDR.Microbiology spectrum · 2026Article
- Blood culture time to positivity in pediatric patients with bloodstream infection in rural Gambia.IJID regions · 2025Article
- Recovery of pathogens with implementation of a weight-based algorithm for pediatric blood cultures: an observational intervention study.BMC pediatrics · 2024Observational
- Finding significant pathogens in blood cultures in children: Should we set the timer to 36 hours?Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- The Yield of One vs. Two Blood Cultures in Children: Under-Detection and Over-Testing.Antibiotics (Basel, Switzerland) · 2024Article
- Analysis of Blood Culture Collection and Laboratory Processing Practices in Israel.JAMA network open · 2022Article
- [Paediatric Life Support].Notfall & rettungsmedizin · 2021Review
- Challenges of Antibiotic Stewardship in the Pediatric and Neonatal Intensive Care Units.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple blood cultures have been shown to improve pathogen yield and antimicrobial stewardship for adult patients with suspected serious bacterial infection (SBI). For children, the use of multiple blood cultures is less common and volume recommendations are more complicated, often resulting in single cultures with low volume.
methodsIn 2010, Children's Hospital Colorado instituted electronic medical record (EMR) decision support to recommend collection of 2 blood cultures before administration of antibiotics for suspected SBI. Recommended blood culture volumes were calculated by age rather than weight. We evaluated all children admitted to inpatient units between 2008 and 2009 (pre-intervention) and 2011 and 2013 (postintervention) who received antibiotics in the hospital after having blood cultures drawn in the emergency department, excluding those with a length of stay >8 days. We compared blood culture yield, isolate classification (pathogen vs contaminant), and antimicrobial modifications before and after the interventions.
resultsA total of 3948 children were included in the study. EMR guidelines were associated with a significantly higher number of children with multiple blood cultures drawn before antibiotic administration (88.0% vs 12.3%;
conclusionsMultiple blood cultures with age-based volumes taken before starting antibiotics increase pathogen isolation rates and appropriate modification of antimicrobial treatment in children.
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